HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

By E. Laughner, P. Taghavi, K. Chiles, P. Mahon, G. Semenza. Molecular and Cellular Biology, 2001

1,324 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/e9fbd8f44bde7e5bc7c92f6e61b0a194e07c5eab

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Semenza
2. David M. Sabatini
3. C. V. Dang
4. Ralph J. Deberardinis
5. M. V. Vander Heiden
6. Richard J. Johnson
7. N. Prabhakar
8. J. Espinosa

In Molecular Biology

1. David M. Sabatini
2. C. V. Dang
3. G. Semenza
4. Ralph J. Deberardinis
5. M. V. Vander Heiden
6. M. Laplante
7. B. Manning
8. Navdeep S. Chandel

In Oncology

1. G. Semenza
2. M. V. Vander Heiden
3. C. V. Dang
4. J. Espinosa
5. David M. Sabatini
6. R. Abraham
7. V. L. Dengler
8. E. Olson

Citations in the corpus

• Regulation of mTORC1 and its impact on gene expression at a glance (2013, background): “As is the case for mTORC1, HIF1a activity is also frequently elevated in cancer.”
• Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth (2008, neutral): “These genetic alterations activate the mammalian target of rapamycin (mTOR), a serine-threonine protein kinase that activates p70 S6 kinase, which phosphorylates ribosomal protein S6 (RPS6) and induces increased translation of HIF-1 mRNA into protein (14).”
• Otto Warburg's contributions to current concepts of cancer metabolism (2011, background): “,it can also increase the activity of HIF1, further enhancing induction of glycolysi”
• IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis (2003, background): “Although some stimuli can promote HIF-1α protein up-regulation as a result of increased translation (56), our data suggest that IL-1 up-regulates HIF-1α by stabilizing the protein.”
• Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin (2002, background): “The negative effect of rapamycin on HIF-1 stability was somewhat unexpected, based on the recent report by Semenza and coworkers ( 26 ).”
• HIF-1 as a target for drug development (2003, background): “This overexpression of HIF-1α is due to both hypoxia-dependent as well as hypoxia-independent pathways, such as oncogene activation and glucose deprivatio”
• The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche (2010, background): “Upregulation of Hif-1a can occur either by transcriptional activation (Hirota et al., 2004; Laughner et al., 2001) or protein stabilization (Li et al.”
• The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis (2007, background): “…overexpression leads to increased expression of hypoxia-inducible factor 1a (HIF-1a) through Akt leading to increased expression of vascular endothelial growth factor (VEGF) and increased surface expression of fibronectin receptors (Laughner et al., 2001; Li et al., 2005; Spangenberg et al., 2006).”
• HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. (2013, neutral): “…α synthesis as a result of PI3K and AKT signaling that stimulates mTOR activity, which stimulates translation of HIF1A mRNA into protein by phosphorylation of eIF4E binding protein (78, 80). mTOR has also been reported to stimulate HIF-1 α stabilization and transactivation domain function (81).”
• Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy (2006, neutral): “…translation of HIF-1a messenger RNA through the phosphatidylinositol 30-kinase and mitogen-activated protein kinase (MAPK) pathways (Brune & Zhou 2003, Fukuda et al. 2002, Fukuda et al. 2003, Laughner et al. 2001, Lukiw et al. 2003, Minet et al. 2001, Pichiule et al. 2004, Semenza 2001a).”