HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations.
By G. Semenza. Journal of Clinical Investigation, 2013
1,235 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6adf2a95c649cd68b00e67ec9045f9f250d1d774
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Citations in the corpus
- An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma (2016, neutral): “One of the key HIF1 targets in glycolysis is pyruvate dehydrogenase kinase, which phosphorylates and inhibits pyruvate dehydrogenase (PDH), thereby impeding fueling of pyruvate-derived carbons to the TCA cycle (Gordan et al., 2007; Kaelin, 2008; Semenza, 2013).”
- Glutaminolysis: A Hallmark of Cancer Metabolism. (2017, background): “Furthermore, activation of HIF1 can promote E3 ubiquitin–protein ligase SIAH2–dependent ubiquitination and subsequent degradation of oxoglutarate dehydrogenase 2 (OGDH2), a key enzyme for α-ketoglutarate conversion into succinate (58).”
- Vitamin C physiology: the known and the unknown and Goldilocks (2016, neutral): “As reviewed elsewhere, HIF-1 has a role in the control of erythropoiesis (Franke et al., 2013); in lung disease (Shimoda & Semenza, 2011); in heart disease (Semenza, 2014); in diabetes (Catrina, 2014, Ichiki & Sunagawa, 2014); and in cancer (Semenza, 2013) (Borsi et al., 2015) .”
- The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy (2015, background): “…facilitates tumor growth by promoting angiogenesis via VEGF and SDF-1, 50,51 metabolism via regulation of GLUT-1, GLUT-3, and glycolytic enzymes, 52–54 and regulating cell apoptosis and cell survival via BNIP-3, 55 p53, 56,57 TGF-β , and bFGF. 3 Moreover, HIF-α contributes to cancer metastasis by…”
- The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism (2014, background): “, VHL), activation of oncogenic signaling, and increased ROS levels [52], [55].”
- Metabolic reprogramming and cancer progression (2020, background): “Hypoxic regions within tumors portend an increased risk of metastasis, and transcriptional programs downstream of HIF-1 and HIF-2 allow hypoxic breast cancer cells to intravasate and metastasize (67, 68).”
- Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “HIFs regulate a switch from glucose to glutamine metabolism to produce acetyl-CoA in fatty acid synthesis (Semenza, 2013).”