IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

By Yunjin Jung, J. Isaacs, Sunmin Lee, J. Trepel, L. Neckers. 2003

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Regulation of Immune Responses by Prostaglandin E2 (2012, background): “Because PGE2 participates in the induction of hypoxia-inducible factor-1a (118), the hypoxia-inducible factor-1a–mediated development of MDSCs (119) is likely to represent a central downstream signaling event in the PGE2-mediated impact on MDSC development.”
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “induced in cancer cells by inflammatory cytokines (TNF and IL-1β), PGE2 [104] and reactive”
Inflammation, a Key Event in Cancer Development (2006, background): “The relationship between regulation of NF-nB and HIF-1 pathways is dependent on the status of cells (83, 194, 196, 197).”
Tumour-educated macrophages promote tumour progression and metastasis (2004, background): “They produce IL-1, which — through cyclooxygenase 2 (COX 2) — upregulates HIF-1α, resulting in an increase in the transcription of VEGF”