Regulation of mTORC1 and its impact on gene expression at a glance

By M. Laplante, David M. Sabatini. Journal of Cell Science, 2013

688 citations recorded by the source corpus.

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Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “mTORC1 can promote the synthesis of proteins, lipids, and nucleotides by integrating various stimuli and signaling networks and can block catabolic processes such as autophagy.(132,133) Studies”
MYC, Metabolism, and Cancer. (2015, background): “These studies collectively indicate that nutrient sufficiency and growth factor signaling are required for MYC to carry out its transcriptional program— a transcriptional program that serves to propagate the translational growth program triggered by mTOR, a key activator of cap-dependent translation”
Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system (2016, background): “Previous studies from many laboratories have shown that impaired mTORC1 activation results in smaller cells and smaller mice (10, 21).”
mTOR: a pharmacologic target for autophagy regulation. (2015, neutral): “17, 18).”