Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

By Huafeng Zhang, D. Qian, Yee Sun Tan, KangAe Lee, Ping Gao, Yunzhao R. Ren, S. Rey, H. Hammers, Daniel J Chang, R. Pili and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2008

623 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ad3fa6ccad907da0a52a0b821d2be70006a9b6fd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, methodology): “This hypothesis was tested by the daily administration of digoxin, a cardiac glycoside that has been used to treat congestive heart failure and cardiac arrythmias for decades, which inhibits the synthesis of HIF-1 protein (379).”
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “HIF-1 is directly involved in regulating mitochondrial autophagy by inducing expression of the BH3-only proteins BNIP3 andBNIP3L,whichpromotes release of Beclin-1, a major autophagy regulator (Zhang et al., 2008a; Bellot et al., 2009).”
Pyruvate Kinase M2 is a PHD3-stimulated Coactivator for Hypoxia-Inducible Factor 1 (2011, result): “LDHA, PDK1, and GLUT1 protein levels were also significantly reduced in HeLa cells transduced with shPKM2 retrovirus, which was comparable to the effect of treatment with digoxin (Figure 7B and Figure S6B), a drug that inhibits HIF-1a synthesis (Zhang et al., 2008).”
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy (2012, background): “Drugs that inhibit the translation of HIF-1α mRNA into protein include: (i) mTOR inhibitors, such as rapamycin, temsirolimus (CCI-779), and everolimus (RAD-001) [50]; (ii) cardiac glycosides, such as digoxin [51], which have been used for decades to treat heart disease; (iii) microtubule targeting a”
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. (2011, neutral): “Other transcription factors have been identified to contribute to the induction of IL-17A in TH17- polarized cells: Runx1 (Zhang et al., 2008), BATF (Schraml et al.”