The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

By K. Suzuki, T. Kirisako, Y. Kamada, N. Mizushima, Takeshi Noda, Y. Ohsumi. EMBO Journal, 2001

1,061 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e9e8a80f76798bbb6abbf27aefd9126acf1f3d3e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. D. Klionsky
2. N. Mizushima
3. Beth Levine
4. I. Slaninová
5. Y. Ohsumi
6. Zhifen Yang
7. V. Deretic
8. T. Yoshimori

In Epidemiology

1. D. Klionsky
2. N. Mizushima
3. Beth Levine
4. I. Slaninová
5. Guido Kroemer
6. V. Deretic
7. Alec C. Kimmelman
8. Y. Ohsumi

In Molecular Biology

1. N. Mizushima
2. D. Klionsky
3. Beth Levine
4. Y. Ohsumi
5. Guido Kroemer
6. V. Deretic
7. T. Yoshimori
8. P. Codogno

Citations in the corpus

• Dynamics and diversity in autophagy mechanisms: lessons from yeast (2009, background): “However, fluorescence microscopy showed that one dot of fluorescently tagged Atg8 is usually observed in close proximity to the vacuole in each cel”
• mTOR regulation of autophagy (2010, background): “In line with the role of ULK in the regulation of the two conjugation systems, Vps34 complex was found to play an essential role in the recruitment of Atg8–PE and the Atg5–Atg12 conjugates to the pre-autophagosomal structure in yeast [92].”
• Autophagy: molecular machinery for self-eating (2005, background): “protein is required for the recruitment of the Atg12–Atg5Atg16 complex and Atg8–PE to the PAS.(5) In contrast, Atg1 and Atg2 are not needed for the PAS localization of the conjugates,(5) suggesting that Atg9 retrieval from the PAS, which depends on Atg1 and Atg2, is also not important in this regard”
• Autophagy: dual roles in life and death? (2005, background): “The isolation membrane that encloses cargo is derived from a pre-autophagosomal structure that seems to be under positive control of the class III PI3K signalling complex and includes the autophagy regulator Atg6 (also known as Beclin1”
• Regulation and role of autophagy in mammalian cells. (2004, background): “…the formation of autophagosomes is dependent upon two conjugation systems reminiscent of the ubiquitination of proteins in the proteo- somal pathway (Ohsumi, 2001) that function in coordinated manner (Nemoto et al., 2003; Suzuki et al., 2001; Tanida, Tanida-Miyake, Komatsu, Ueno, & Kominami, 2002).”
• Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (2008, background): “Yeast Atg8 lipidation also occurs in atg1, 2, 6, 9, 13, 14, 16, and 17 mutants (Suzuki et al., 2001), and vps15 and vps34 mutants (Obara et al.”
• In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. (2003, background): “The resulting conjugates, Atg12-Atg5 and Atg8-PE, function in autophagosome formation (Suzuki et al., 2001; Noda et al., 2002).”
• Autophagy as a regulated pathway of cellular degradation. (2000, neutral): “somes (43), providing additional evidence for”
• Autophagy and autophagy-related proteins in cancer (2020, background): “As a dock structure for recruitment of ATG proteins, PAS plays a critical role during induction of autophagy [34, 35] Under autophagy-inducing conditions, the functional unit ULK1/Atg1 (including ULK1, ATG13, FIP200, and ATG101) acts as autophagy initiation complex, in which the ATG13 is a crucial p”