mTOR regulation of autophagy

By C. Jung, Seung-Hyun Ro, Jing Cao, N. Otto, Do-Hyung Kim. FEBS Letters, 2010

2,072 citations recorded by the source corpus.

Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily‐conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although TOR has been known as a key regulator of autophagy for more than a decade, the underlying regulatory mechanisms have not been clearly understood. This review discusses the recent advances in understanding of the mechanism by which TOR regulates autophagy with focus on mammalian TOR (mTOR) and its regulation of the autophagy machinery.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f9e416ae4c54fd91ab3f45ba01b463686eb1dbcc

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Citations in the corpus

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression (2013, background): “Several signal transduction pathways are known to regulate the induction of autophagy such as mTORC1 and AMPK, in response to nutrient availability (32,62,63).”
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, background): “161 Moreover, the precise role of autophagy in human malignancies is still not clear because activation or suppression of autophagy was found to be tumorigenic or anti-tumorigenic.”
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 (2011, background): “The inhibitory function of mTOR complex 1 (mTORC1) in autophagy is well establishe”
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Anoikis molecular pathways and its role in cancer progression. (2013, background): “Induction of autophagy is driven by the activation of proteins that sense cellular metabolic stress, such as AMP activated protein kinase (AMPK) [121,146].”