Autophagy as a regulated pathway of cellular degradation.

By D. Klionsky, S. Emr. Science, 2000

3,758 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Parasitology

View Paper: https://www.semanticscholar.org/paper/b4ae161c210d00481053d896e99467979b28d344

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Citations in the corpus

Ubiquitin and proteasomes: Molecular dissection of autophagy: two ubiquitin-like systems (2001, background): “During the past decade, however, molecular biological approaches using the yeast Saccharomyces cerevisiae as a model system have begun to uncover the secrets of autophag”
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. (2007, neutral): “Macroautophagy (hereafter referred to as autophagy) is a conserved catabolic process for the removal of longlived proteins, organelles, and bulk cytoplasm (Klionsky and Emr, 2000).”
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability (2011, background): “Autophagy is a self-degradation process induced, for example, when nutrients are limite”
Autophagy: dual roles in life and death? (2005, background): “Two general mechanisms are used for large-scale degradation of components of the cytoplasm; short-lived regulatory proteins are destroyed by the ubiquitin–proteasome system, and long-lived structures and proteins are targeted to the lysosome by autophag”
Ferroptosis: mechanisms and links with diseases (2021, background): “The process that removes intracellular components such as unused proteins and damaged organelles through lysosomes, was named “autophagy” in 1963.(159) Autophagy plays a multifaceted role in regulating both the quality and quantity of proteins and organelles,(160) therefore it determines cell fate v”
Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “Autophagy (also known as macroautophagy) is the major pathway involved in the degradation of long-lived proteins (Klionsky and Emr, 2000).”
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. (2005, background): “…apoptotic pathway, nutrient deprivation results in compromised bioenergetics and activation of a cell survival response termed macroautophagy (Klionsky and Emr, 2000; Takeshige et al., 1992; Thumm et al., Julian J. Lum,1 Daniel E. Bauer,1 Mei Kong,1 Marian H. Harris,1 Chi Li,1 Tullia…”
Apoptosis: A Review of Programmed Cell Death (2007, background): “Other terms used synonymously are “macroautophagy” and “autophagic type II cell death” (Klionsky and Emr, 2000).”
LC3 conjugation system in mammalian autophagy (2004, background): “The proteins involved in the autophagic process in yeast have been isolated and characterized (Harding, Morano, Scott, & Klionsky, 1995; Thumm et al., 1994; Tsukada & Ohsumi, 1993) (for reviews (Klionsky, 2004; Klionsky & Emr, 2000; Ohsumi, 2001; Stromhaug & Klionsky, 2001; Thumm, 2000)).”
Regulation and role of autophagy in mammalian cells. (2004, background): “Identification of its molecular machinery and signaling pathways has shed some light on the importance of autophagy in physiological processes and diseases (Klionsky & Emr, 2000) (seeFig.”
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. (2007, methodology): “Virgin female flies of genotype y w; gmr-httNterm(1-171)Q120 (gmrQ120)22 were mated with isogenised w1118 males28 in food vials for 48 h.”