Autophagy: dual roles in life and death?

By Eric H. Baehrecke. Nature reviews. Molecular cell biology, 2005

1,034 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/81c3d757d48849fc0d6c683d9f262f799121ac9a

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In Cell Biology

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In Epidemiology

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In Molecular Biology

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Citations in the corpus

• Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. (2007, background): “Recent studies indicate that autophagy may play an active role in programmed cell death, but the conditions under which autophagy promotes cell death versus cell survival remain to be resolved (Baehrecke 2005; Debnath et al. 2005).”
• Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. (2006, background): “Some cytosolic proteins are degraded in lysosomes after being engulfed in autophagic vacuoles that fuse with lysosomes (3,4).”
• Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis (2008, background): “Baehrecke EH. (2005). Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 6: 505–510.”
• Classification of cell death (2005, neutral): “In contrast to apoptotic cells (whose clearance is ensured by engulfment and lysosomal degradation), cells that die with an autophagic morphology have little or no association with phagocytes.(40,41) Although the expression ‘autophagic cell death’ is a linguistic invitation to believe that cell deat”
• Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. (2007, neutral): “Caspase-Independent Degradation Pathways Are Required for Autophagic Cell Death Given autophagy’s well-established function in cell survival, a role for autophagy in cell death seems paradoxical (Baehrecke, 2005; Levine and Yuan, 2005).”
• Bcl-2 family proteins and cancer (2008, background): “Indeed, circumstances have been identified where autophagy is induced and where Bcl-2 or Bcl-XL either suppress or promote cell death, through mechanisms requiring components of the autophagic machinery (Baehrecke, 2005; Meier and Vousden, 2007).”