Autophagy: molecular machinery for self-eating

By Tomohiro Yorimitsu, D. Klionsky. Cell Death and Differentiation, 2005

1,589 citations recorded by the source corpus.

Subfields: Biochemistry, Cell Biology, Epidemiology

View Paper: https://www.semanticscholar.org/paper/a74dae7b1bded726508a656bcf358a0a6729f723

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. D. Klionsky
2. G. Hotamışlıgil
3. N. Mizushima
4. Donna D. Zhang
5. Alec C. Kimmelman

In Cell Biology

1. D. Klionsky
2. N. Mizushima
3. Zhifen Yang
4. E. White
5. Y. Ohsumi
6. Katherine R Parzych
7. G. Hotamışlıgil
8. Zhiping Xie

In Epidemiology

1. D. Klionsky
2. N. Mizushima
3. E. White
4. Beth Levine
5. Guido Kroemer
6. Zhifen Yang
7. Katherine R Parzych
8. Y. Ohsumi

Citations in the corpus

• The role for endoplasmic reticulum stress in diabetes mellitus. (2008, background): “During autophagy, parts of the cytoplasm, including its organelles, are sequestered into membrane-bound compartments that then fuse with lysosomes where their content is degraded by acid hydrolases (118).”
• A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62 (2010, background): “Autophagy plays a major role in maintaining cellular homeostasis during nutrient deprivation and in eliminating damaged proteins and organelles that accumulate during stress (25).”
• Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance (2010, background): “Autophagy is a highly regulated process involved in the turnover of long-lived proteins, cytosolic components, or damaged organelles (Yorimitsu and Klionsky, 2005).”
• Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. (2007, background): “…functional groups: (i) the Atg1 protein kinase complex, (ii) the Atg14-contain- ing phosphatidylinositol-3 kinase complex, (iii) the Atg12- Atg5 protein conjugation system, (iv) the Atg8 lipid conjugation system, and (v) the Atg9 membrane protein recycling system (Yorimitsu and Klionsky, 2005).”
• Molecular characterization of LC3-associated phagocytosis (LAP) reveals distinct roles for Rubicon, NOX2, and autophagy proteins (2015, positive): “The lipidated, membrane-associated LC3-II is associated with both outer and inner autophagosomal membranes and remains on autophagosomes during formation, completion and fusion with the lysosome 39,40 .”
• Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. (2007, background): “Autophagy is an evolutionarily conserved catabolic process whereby cytoplasmic proteins and organelles are targeted to lysosomes for degradation (Klionsky and Emr 2000; Mizushima 2005; Yorimitsu and Klionsky 2005).”
• An Overview of the Molecular Mechanism of Autophagy (2009, background): “4 of Yorimitsu and Klionsky (2005b) Curr Top Microbiol Immunol.”