Dynamics and diversity in autophagy mechanisms: lessons from yeast

By H. Nakatogawa, Kuninori Suzuki, Y. Kamada, Y. Ohsumi. Nature reviews. Molecular cell biology, 2009

1,737 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/ddd242ebc4901cc52d70a9ff39b117c09769dd8f

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Citations in the corpus

Mechanisms of mitophagy (2011, background): “jpg"/> Autophagy is the process of catabolism of cellular components, such as the cytosol, organelles and protein aggregates, through their encapsulation by a double-membrane structure known as the autophagosom”
Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks (2011, background): “These proteins can be classified into several groups depending on their function and interdependency (81).”
Selective autophagy mediated by autophagic adapter proteins (2011, background): “Yeast genetics has been vital for the elucidation of the molecular machinery involved in autophagy processes.(2,6) So far, 34 AuTophaGy-related (ATG) genes have been reported in yeast and 15 of these are “core” ATG genes commonly required for the different autophagy pathways.”
Programmed Cell Death in Animal Development and Disease (2011, neutral): “This is dependent upon a large group of autophagyrelated (ATG) genes, which are conserved from yeast to human (Nakatogawa et al., 2009).”
PI(5)P Regulates Autophagosome Biogenesis (2015, background): “The class III phosphatidylinositol 3-kinase (also known as VPS34) and its product phosphatidylinositol 3-phosphate (PI(3)P) are critical for autophagosome formation (Boya et al., 2013; Nakatogawa et al., 2009).”
The dynamic nature of autophagy in cancer. (2011, background): “A key set of autophagy-related genes (ATGs), which are essential for the process, were identified in a series of seminal studies in the yeast system and have moved the field into the molecular era (Nakatogawa et al. 2009).”
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy (2013, background): “These processes are coordinated by ATG proteins; among them the ULK1 and Vps34 complexes are well known to function as important regulators in autophagy initiation and progression (Nakatogawa et al., 2009; Suzuki et al., 2007).”
Nix is a selective autophagy receptor for mitochondrial clearance (2010, background): “Its main hallmark is the formation of double-membrane vesicles—autophagosomes—that engulf cargo and deliver it to lysosomes for degradation (Xie & Klionsky, 2007; Nakatogawa et al, 2009).”
Autophagy: Renovation of Cells and Tissues (2011, background): “The core Atg proteins are shared by other autophagy-related pathways, such as pexophagy (autophagic degradation of the peroxisome) and the cytoplasm-to-vacuole targeting pathway, which have been discussed in more detail in other reviews (Chen and Klionsky, 2011; Nakatogawa et al., 2009; Youle and Na”
Septins: the fourth component of the cytoskeleton (2012, background): “Given the common machinery used for autophagy from yeast to human”
The regulation of autophagy – unanswered questions (2011, background): “which functions in autophagy, consists of Atg6 (Vps30), Atg14, Vps34 (the only PtdIns3K in yeast) and Vps15, whereas complex II contains Vps38 instead of Atg14 and functions in the vacuolar protein sorting (Vps) pathway (Cao and Klionsky, 2007; Nakatogawa et al., 2009).”