Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage

By N. Kessaris, M. Fogarty, P. Iannarelli, Matthew Grist, M. Wegner, W. Richardson. Nature Neuroscience, 2005

1,155 citations recorded by the source corpus.

The developmental origin of oligodendrocyte progenitors (OLPs) in the forebrain has been controversial. We now show, by Cre-lox fate mapping in transgenic mice, that the first OLPs originate in the medial ganglionic eminence (MGE) and anterior entopeduncular area (AEP) in the ventral forebrain. From there, they populate the entire embryonic telencephalon including the cerebral cortex before being joined by a second wave of OLPs from the lateral and/or caudal ganglionic eminences (LGE and CGE). Finally, a third wave arises within the postnatal cortex. When any one population is destroyed at source by the targeted expression of diphtheria toxin, the remaining cells take over and the mice survive and behave normally, with a normal complement of oligodendrocytes and myelin. Thus, functionally redundant populations of OLPs compete for space in the developing brain. Notably, the embryonic MGE- and AEP-derived population is eliminated during postnatal life, raising questions about the nature and purpose of the competition.

Subfields: Developmental Neuroscience, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/e8f1e263e62cac496b3a6ce7ac9e4026a2da129a

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Citations in the corpus

Molecular Architecture of the Mouse Nervous System (2018, background): “by genetic lineage tracing of Emx1-positive neural progenitors, which selectively labels forebrain oligodendrocytes (Kessaris et al., 2006).”
NG2 cells generate both oligodendrocytes and gray matter astrocytes (2007, background): “Curiously, there seems to be a reciprocal distribution of EGFP+ astrocytes and oligodendrocytes derived from Emx1-expressing cortical progenitor cells (Kessaris et al., 2006).”
CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination (2010, neutral): “The Olig2-cre line drove Cre recombination in all oligodendrocyte-lineage cells and motor neurons (Kessaris et al., 2006).”
Developmental genetics of vertebrate glial–cell specification (2010, neutral): “The precise origins of forebrain OPCs have been explored using Cre– loxP fate mapping in transgenic mic”
Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain (2006, background): “This early wave of oligodendrocytes is transitory and superseded by oligodendrocytes originating latter in development from dorsal telencephalic sources (Kessaris et al., 2006).”
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. (2009, background): “…CNS. Previous work has indicated that oligodendrocytes are born in multiple waves during development (Cai et al. 2005; Vallstedt et al. 2005; Kessaris et al. 2006) and that neonatal and adult oligodendrocytes may have a dramatically different response to injury (Back et al. 2002), possibly…”
Astrocytes and disease: a neurodevelopmental perspective. (2012, background): “) Such regulatory elements could be used to drive conditionally inducible genes affecting astrocyte function, as has been done with oligodendrocyte precursors (Kessaris et al. 2006).”
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system (2016, neutral): “A largely homogeneous population is thought to execute these functions throughout the CNS (1).”
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity (2009, background): “It is possible that dorsal polydendrocytes derived from the EMX1-expressing precursors found in these regions have a lower astrogliogenic potential than the more ventral polydendrocytes derived from GSH2-expressing precursor”
The origin and specification of cortical interneurons (2006, background): “In addition, migration from the LGE to cortex has been shown to include oligodendrocytes after E14.5 ( Kessaris et al. 2006 ).”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “After E18, yet another wave of cortical oligodendrocytes arise, this time from Emx1-expressing precursor cells presumably from dorsal cortex itself (Gorski et al. 2002, Kessaris et al. 2006).”
Remyelination in the CNS: from biology to therapy (2008, background): “and the developmental heterogeneity of the oligodendrocyte lineag”