Astrocytes and disease: a neurodevelopmental perspective.

By A. Molofsky, Robert Krencik, E. Ullian, Hui-hsin Tsai, B. Deneen, W. Richardson, B. Barres, D. Rowitch. Genes & Development, 2012

653 citations recorded by the source corpus.

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies indicate that astrocytes are morphologically and functionally diverse and play critical roles in neurodevelopmental diseases such as Rett syndrome and fragile X mental retardation. This review summarizes recent advances in astrocyte development, including the role of neural tube patterning in specification and developmental functions of astrocytes during synaptogenesis. We propose here that a precise understanding of astrocyte development is critical to defining heterogeneity and could lead advances in understanding and treating a variety of neuropsychiatric diseases.

Subfields: Developmental Neuroscience, Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/6bcf00e207a1f2dce81f2f9c46f6e1b578376be2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. B. Barres
2. M. Sofroniew

In Neurology

1. S. A. Liddelow
2. C. Zhong
3. B. Barres
4. Zhichun Chen
5. R. Daneman
6. Berislav Zlokovic
7. M. Sofroniew
8. M. Pekny

Citations in the corpus

• Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse (2015, neutral): “They obtained transcriptome profiles of purified human CNS cell types and discovered two distinct stages of human astrocyte development.”
• Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “on the function of astrocytes participating in the composition of blood brain barrier (BBB) (Molofsky et al., 2012) and various”
• An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex (2014, background): “…spectrum disorders, epilepsy, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and stroke (Matute et al., 2005; Tian et al., 2005; Nagai et al., 2007; Chen et al., 2009; Li et al., 2011; Lioy et al., 2011; Molofsky et al., 2012; Zamanian et al., 2012).”