NG2 cells generate both oligodendrocytes and gray matter astrocytes

By Xiaoqin Zhu, D. Bergles, A. Nishiyama. Development, 2007

673 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/293de7615b52c6932448e61082bf9de59657cf91

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Citations in the corpus

NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. (2010, methodology): “to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration”
Physiology of Astroglia. (2018, neutral): “Another possible source of astroglia may be associated with NG2 glial cells (1227), which can generate protoplasmic astrocytes that stay strictly in the ventral forebrain and do not migrate to other areas; furthermore, this astrogenic route seems to be temporally limited (748, 1959, 1960).”
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity (2009, background): “These mice and the NG2DsRedBAC-transgenic mice, in which the red fluorescent protein DsRed is expressed under the regulatory control of the Cspg4 gen”
Split-Cre Complementation Indicates Coincident Activity of Different Genes In Vivo (2009, methodology): “NG2+ cells have been referred to as oligodendrocyte precursor cells for a long time, but very recent evidence suggests that NG2+ cells (besides numerous other functions [44]) generate oligodendrocytes as well as gray matter astrocytes in vivo, the latter most likely via a transition state which is N”
Mosaic Analysis with Double Markers (MADM) Reveals Tumor Cell-of-Origin in Glioma (2011, neutral): “To address this question, we next used NG2-Cre that has been reported to specifically express in OPCs, but not NSCs (Komitova et al., 2009; Zhu et al., 2008), to perform MADM analysis.”
CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination (2010, neutral): “OLPs can be induced to generate GFAP + cells in vitro (Raff et al., 1983) and there is some evidence that this differentiation pathway is followed during normal development and adulthood (Levison and Goldman, 1993; Zhu et al., 2008).”
Heterogeneity of Astrocytic Form and Function (2012, neutral): “Furthermore, protoplasmic astrocytes may also be generated postnatally from NG2+ glial progenitor cells arising from the SVZ of the ganglionic eminences and later ventral striatum (51).”
The Glymphatic System – A Beginner's Guide (2015, neutral): “Using reporter mice to distinguish arteries from veins (Ds-red fluorescent protein expressed under the NG2 promoter in pericytes and smooth muscle cells) [68, 69], it was demonstrated that CSF tracers follow arteries at the pial surface running across the cortical surface and descend along penetrati”
Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes (2015, positive): “The following transgenic mice were used: NG2cre (Zhu et al., 2008) (Jackson Labs number 008533), NG2creER (Zhu et al., 2011) (Jackson Labs number 008538), floxed ChR2-YFP (Madisen et al., 2012) (Jackson Labs number 012569), SMA-mCherry (Armstrong et al., 2010); SMAcreER (Wendling et al., 2009), mT/m”