Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

By A. Nishiyama, Mila Komitova, Ryusuke Suzuki, Xiaoqin Zhu. Nature Reviews Neuroscience, 2009

855 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/004f3ca698c9fef701df87d683108bb5893eaa09

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Citations in the corpus

Cellular and Molecular Characterization of Multipolar Map5-Expressing Cells: A Subset of Newly Generated, Stage-Specific Parenchymal Cells in the Mammalian Central Nervous System (2013, background): “In the adult mammalian CNS, beside de novo cell genesis of ‘classic’ neurogenic sites (SVZ and dentate gyrus [62,63]), the occurrence of local, parenchymal progenitors which continue to divide throughout life has progressively became a new area of investigation [1,2,64,65].”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “These assumptions have been recently challenged by data showing that neurogenesis also occurs in several other regions of the CNS, such as neocortex, cerebellum, striatum, amygdala, and substantia nigra (51, 85, 94, 134, 159, 180) and more recently also in the hypothalamus (75, 85, 109, 110, 170) an”
Physiology of Astroglia. (2018, neutral): “Occasional recordings of T- and L-type Ca(2) currents from cells in young hippocampal slices (19) were, most likely, obtained from NG2 glia, which, in contrast to astrocytes, has more “excitable” phenotype (1228).”
Heterogeneity of Astrocytic Form and Function (2012, neutral): “NG2 cells may be viewed as a separate class of glial cells and are characterized by a lack of gap junction coupling, high input resistance, and voltagedependent sodium and potassium conductances (36).”
Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, positive): “It has also been previously suggested that the NG2 cells in the adult SVZ are Type C cells; however, as recently reviewed there are multiple lines of evidence supporting that NG2 cells are not a source of neurons in the naı̈ve adult rodent brain (Nishiyama et al., 2009; Trotter et al., 2010).”
Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. (2014, background): “aptic associations with neurons through which they receive excitatory synaptic inputs (343, 361, 494).”
Origin of new glial cells in intact and injured adult spinal cord. (2010, background): “Oligodendrocyte progenitors express NG2 and are also referred to as NG2 cells or polydendrocytes (Nishiyama et al., 2009).”
NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. (2010, background): “…zone of the dentate gyrus, the adult brain and spinal cord contain a widely distributed, abundant class of progenitors known as NG2+ cells (also termed oligodendrocyte precursor cells [OPCs]) because they express the chondroitin sulfate proteoglycan NG2 (Nish- iyama et al., 2009); nearly all (99”