CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination
By M. Zawadzka, L. Rivers, S. Fancy, Chao Zhao, Richa Tripathi, F. Jamen, K. Young, A. Goncharevich, H. Pohl, M. Rizzi and 5 more. Cell Stem Cell, 2010
636 citations recorded by the source corpus.
SUMMARY After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics
View Paper: https://www.semanticscholar.org/paper/59d5a0ddd629c26eada57028433720eef7c91df8
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In Cellular and Molecular Neuroscience
- A. Tran
- P. Warren
- J. Silver
- David Attwell
- Jeffrey D. Rothstein
- D. Bergles
- Lisa Feldman Barrett
- Peter Sterling
In Developmental Neuroscience
In Genetics
Citations in the corpus
- The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “Some Schwann cells occupying the lesion site (41, 45) have also been shown to differentiate from NG2 OPCs (437).”
- NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. (2010, background): “…diseases such as Alzheimer’s and Parkinson’s disease (Ilieva et al., 2009), and following stroke and acute CNS trauma, it is possible that NG2+ cells exhibit greater lineage plasticity in response to different disease and injury conditions (Sellers et al., 2009; Zawadzka et al., 2010).”
- In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high fat feeding (2012, neutral): “PDGFRa progenitors comprise 5% of cells in brain and contribute to oligodendrocyte formation in adults and CNS remyelination following injury (Zawadzka et al., 2010).”
- Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013, background): “Consistent with that, we found that adult-born OLs elaborated much shorter but many more internodes than OLs generated during early postnatal life.”