Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain

By B. Menn, Jose Manuel García-Verdugo, Cynthia Yaschine, Ó. González-Pérez, D. Rowitch, Arturo Alvarez-Buylla. Journal of Neuroscience, 2006

1,015 citations recorded by the source corpus.

Glial fibrillary acidic protein (GFAP)-positive astrocytes (type B cells) in the subventricular zone (SVZ) generate large numbers of new neurons in the adult brain. SVZ stem cells can also generate oligodendrocytes in vitro, but it is not known whether these adult primary progenitors generate oligodendrocytes in vivo. Myelin repair and oligodendrocyte formation in the adult brain is instead associated with glial-restricted progenitors cells, known as oligodendrocyte progenitor cells (OPCs). Here we show that type B cells also generate a small number of nonmyelinating NG2-positive OPCs and mature myelinating oligodendrocytes. Some type B cells and a small subpopulation of actively dividing type C (transit-amplifying) cells expressed oligodendrocyte lineage transcription factor 2 (Olig2), suggesting that oligodendrocyte differentiation in the SVZ begins early in the lineage. Olig2-positive, polysialylated neural cell adhesion molecule-positive, PDGF receptor α-positive, and β-tubulin-negative cells originating in the SVZ migrated into corpus callosum, striatum, and fimbria fornix to differentiate into the NG2-positive nonmyelinating and mature myelinating oligodendrocytes. Furthermore, primary clonal cultures of type B cells gave rise to oligodendrocytes alone or oligodendrocytes and neurons. Importantly, the number of oligodendrocytes derived from type B cells in vivo increased fourfold after a demyelinating lesion in corpus callosum, indicating that SVZ astrocytes participate in myelin repair in the adult brain. Our work identifies SVZ type B cells as progenitors of oligodendrocytes in normal and injured adult brain.

Subfields: Cancer Research, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/c4191ff02dab3bc63b04d0f00476e55b25a9002e

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Citations in the corpus

Remyelination in the CNS: from biology to therapy (2008, background): “or from the type B, intermediate filament glial-fibrillary acidic protein (GFAP)-expressing stem cells of the SVZ perse”
The effect of substrate stiffness on adult neural stem cell behavior. (2009, background): “Oligodendrocyte differentiation is not preferred, but can be stimulated after injury and when remyelination is required [52].”
White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes (2018, neutral): “progenitors migrate to white matter tracks from there [59].”
A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb (2008, background): “2 E), with the remainder expressing the TF Olig2 (Hack et al., 2004, 2005; Menn et al., 2006; Colak et al., 2008) or Mash1 (Fig.”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, methodology): “We still do not know whether single RG during development or adult SVZ B cells can give rise to both neurons and oligodendrocytes, but studies in vitro suggest that such bipotential cells probably do exist (He et al. 2001, Menn et al. 2006).”
The Central Nervous System and the Gut Microbiome (2016, background): “Glial progenitors proliferate in the subventricular zone of the forebrain and migrate to various regions of the brain, where they differentiate to oligodendrocytes and astrocytes (Menn et al., 2006).”
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice (2008, background): “In addition, a small fraction of type-C (transit amplifying) cells originating in the SVZ start to express OLIG2 and generate PDGFRA + OLPs and mature oligodendrocytes in the corpus callosum, striatum and fimbria fornix of adult mic”
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity (2009, background): “Recent retroviral labelling studies have shown more directly that GFAP+ type-B cells of the SVZ, which are considered to be neural stem cells, give rise to remyelinating oligodendrocytes in similarly demyelinated corpus callosu”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, neutral): “The transcription factors Dlx2, Mash1, and NeuroD1 are all associated with a neurogenic fate, while Olig2 is primarily gliogenic (Parras et al., 2004; Hack et al., 2005; Marshall et al., 2005; Menn et al., 2006; Petryniak et al., 2007; Gao et al., 2009).”