Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

By Yan Zheng, P. Valdez, D. Danilenko, Yan Hu, S. Sa, Qian Gong, Alexander R. Abbas, Z. Modrusan, N. Ghilardi, F. Sauvage and 1 more. Nature Medicine, 2008

1,996 citations recorded by the source corpus.

Subfields: Dermatology, Immunology

View Paper: https://www.semanticscholar.org/paper/8d432c43765600d6312d48612b3b9bfe65ce5075

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. Dan R. Littman
2. M. Karin
3. V. Kuchroo
4. E. Bettelli
5. S. Rose‐John
6. T. Korn
7. M. Oukka
8. Wenjun Ouyang

In Immunology

1. Dan R. Littman
2. K. Honda
3. D. Artis
4. M. Karin
5. H. Spits
6. V. Kuchroo
7. Shizuo Akira
8. A. Mantovani

Citations in the corpus

• AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch (2011, background): “The protective role of IL-22 is evident in mice deficient in IL-22 via genetic targeting, which are highly susceptible to gastrointestinal infection by the pathogen Citrobacter rodentium”
• Interleukin-22 Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration (2015, positive): “Tissue-resident ILC3s are potent producers of IL-22 after damage, and expression of IL-22 is associated with reduced injury in colitis as well as several non-intestinal tissue damage models 3,4,6-9 .”
• Commensal bacteria protect against food allergen sensitization (2014, methodology): “injection three times per week as previously described (37, 38).”
• Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa (2010, background): “and IL17F [36], IL-22 [37], and IL-23 [38].”
• RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells (2009, background): “In the intestine, IL-22 is produced in an IL-23-dependent way during inflammation and promotes the expression of antimicrobial proteins and molecules involved in tissue repair (such as RegIIIβ, RegIIIγ, S100A8 and S100A9”
• The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “Is there a role of IL-22 in these two models? IL-22 is quickly upregulated in both models (Aujla et al., 2008; Zheng et al., 2008).”
• Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “For example, it has been shown that IL-22 is crucial for control of pulmonary Klebsiella pneumoniae infection or infection of the gastrointestinal tract with Citrobacter rodentium [62,63].”
• Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 (2011, background): “For example, IL-22-producing ILCs are essential for the innate immune response to the enteric bacterium Citrobacter rodentium in the gu”
• Review of ustekinumab, an interleukin-12 and interleukin-23 inhibitor used for the treatment of plaque psoriasis (2010, positive): “IL-17 plays a critical role in epithelial defense, while IL-22 promotes epidermal hyperproliferation and keratinocyte proliferation and host defense proteins.(14,15) Th1 cells require IL-12 to support development, whereas Th17 cells depend on the presence of IL-23 to properly function.”
• The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells (2011, background): “…abundantly present in the intestinal lamina propria and produce IL-22 and/or IL-17 that are important for mucosal immunity against certain extracel- lular pathogens such as Citrobacter rodentium (Mangan et al., 2006; Ota et al., 2011; Tumanov et al., 2011; Wang et al., 2010; Zheng et al., 2008).”