A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

By D. Fogg, C. Sibon, Chaouki Miled, Steffen Jung, P. Aucouturier, Dan R. Littman, A. Cumano, F. Geissmann. Science, 2006

1,117 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/e63e46632f16c81fc453fcd9edeff71dd8b8598f

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In Immunology

Citations in the corpus

Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes (2006, background): “One study has identified a clonogenic bone marrow precursor cell able to produce macrophages and DCs (even in unirradiated recipient mice), but not other myeloid or lymphoid cell”
The origin and development of nonlymphoid tissue CD103+ DCs (2009, background): “The macrophage and DC precursor (MDP; Fogg et al., 2006) gives rise to monocytes and to the common DC precursor (CDP; Liu et al.”
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas (2010, background): “In the bone marrow, a common monocyte-DC precursor (Fogg et al., 2006) gives rise to monocytes and other precursors termed common DC precursors (Naik et al.”
Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow (2007, background): “Lin − c-Kit + CX3CR1 + bone marrow cells isolated from Cx3cr1-gfp mice differentiate exclusively into macrophages and cDCs on a clonal level in vitro and as a population in vivo”
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells (2007, background): “When injected into the blood stream of recipient mice, MDPs expand and diff erentiate into splenic MΦs and DCs (10).”
Transcription factors in myeloid development: balancing differentiation with transformation (2007, background): “, as well as shared macrophage and dendritic-cell progenitor”
Microglial M1/M2 polarization and metabolic states (2016, background): “In comparison with peripheral tissue macrophages and antigen-presenting dendritic cells that originate from bone marrow-derived monocytes (Parwaresch and Wacker, 1984; Fogg et al., 2006), microglia are derived from primitive yolk sac myeloid progenitors that actively seed the brain parenchyma during”
Microglia promote learning-dependent synapse formation through BDNF (2013, background): “Microglia are a self-renewing population (Ajami et al., 2007) with a low turnover rate (Lawson et al., 1992), whereas monocytes and inflammatory macrophages exhibit rapid turnover (van Furth and Cohn, 1968) and are replenished through a CX3CR1 bone marrow precursor population (Fogg et al., 2006).”
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis (2012, positive): “…breakthrough in defining mononuclear phagocyte development in the adult organism was the identification of a clonotypic BM-resident founder cell, termed Macrophage-DC precursor (MDP), that gives rise to peripheral mononuclear phagocytes while having lost granulocyte potential (Fogg et al., 2006).”
Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages (2019, background): “Monocytes derive from a common progenitor called Macrophage Dendritic Cell Precursor (MDP), emphasizing a continuum differentiation potential of monocytes to both inflammatory macrophages and DCs (3).”
Macrophages: development and tissue specialization. (2015, background): “This includes myeloid precursors, such as primitive macrophages (16), macrophage (monocyte)/dendritic cell precursors (MDPs) (32), and common monocyte progenitors (cMOPs) (33), as well as fetal and adult monocytes (26, 34).”
Blood monocytes: development, heterogeneity, and relationship with dendritic cells. (2009, background): “The MDP gives rise to monocytes, several macrophage subsets, and spleen cDCs (11, 12, 14).”
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “However, many DC and macrophage subpopulations [for example, lymphoid organ DC, plasmacytoid DC, skin Langerhans cells (LC), and brain microglia] originate from the MDP independent of monocytes (11, 18), and in some cases, they can even develop directly from the bone marrow (19).”