Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes

By Shalin H. Naik, D. Metcalf, A. Nieuwenhuijze, I. Wicks, Li Wu, Meredith O'Keeffe, K. Shortman. Nature Immunology, 2006

676 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/5e7eb74cacee31377bc0a3a1d60c938f9b2d8917

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In Immunology

1. Steffen Jung
2. M. Guilliams
3. Florent Ginhoux
4. Y. Belkaid
5. F. Geissmann
6. Eric G. Pamer
7. Miriam Merad
8. C. Varol

Citations in the corpus

• Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen (2007, background): “On the other hand, CD11clow immediate splenic DC progenitors (4) contained only 50% EYFP+ cells, suggesting that effi cient recombination is initiated after DC lineage commitment.”
• Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow (2007, background): “CD11c int CD45RA lo CD43 int SIRP-α int MHCII − spleen cells generate all cDCs but no other cells in vitro and in vivo”
• Intestinal lamina propria dendritic cell subsets have different origin and functions. (2009, background): “Given the recent progress in our understanding of the origins of splenic DCs (Geissmann et al., 2003; Fogg et al., 2006; Naik et al., 2006; Onai et al., 2007; Varol et al., 2007; Liu et al., 2007; Waskow et al., 2008; Liu et al., 2009), we hence sought to investigate the functional organization of l”
• Human inflammatory dendritic cells induce Th17 cell differentiation. (2013, background): “A cardinal feature of mouse infDCs is that they are derived from Ly6Chi monocytes and not from committed DC progenitors (Guilliams et al., 2009; León et al., 2007; Naik et al., 2006).”
• The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Downstream Progenitors Pre-classical dendritic cells—A CD11c+MHC-II− proliferative precursor (pre-cDC) with a high clonal efficiency in mouse BM and lymphoid tissues, able to differentiate into CD8+ and CD11b+ cDCs but not into pDCs or macrophages in vivo, was identified by two separate groups (81, ”
• Repertoire of microglial and macrophage responses after spinal cord injury (2011, background): “Upon subsequent MYD88 signalling, these cells differentiate into tumour necrosis factor (TNFα)- and nitric oxide-producing dendritic cell”
• Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo (2007, background): “The lymphoid-organ-resident DCs do not conform to the Langerhans cell paradigm; they develop from bone-marrow precursors within the lymphoid organs without previously trafficking through peripheral tissue”
• Dendritic cells in intestinal immune regulation (2008, positive): “Migratory DCs sample antigen in the tissues before migrating through the lymph to the lymph nodes, whereas lymphoid-tissue resident DCs probably arrive at the tissues from the blood as precursors and develop into DCs in situ”
• Steady-state and inflammatory dendritic-cell development (2007, background): “The Ly6C + inflammatory mouse monocytes produced no detectable DC progeny in lymphoid organs when transferred intravenously into clean, non-irradiated mice, which indicates that they make no contribution to steady-state DC”
• Monocytes give rise to mucosal, but not splenic, conventional dendritic cells (2007, background): “(36), and it will be important to establish the link of these so-called “pre-cDCs” to the MDP.”
• Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species (2016, background): “The existence of two distinct DC lineages is supported by the identification of lineage-defining transcription factors (TFs) required for development and/or function of cDC1 (IRF8, BATF3, ID2) and cDC2 (IRF4, ZEB2) (Breton et al., 2015; Grajales-Reyes et al., 2015; Guilliams et al., 2014; Lee et al.”
• Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. (2007, background): “Studies describing the accumulation of DCs in lymphoid tissues during infection or showing in noninfectious inflammatory conditions that monocytes can differentiate into DCs (Le Borgne et al., 2006; Geissmann et al., 2003; Naik et al., 2006; Randolph et al., 1999; Serbina et al., 2003) suggest that ”