Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow

By N. Onai, Aya Obata-Onai, M. A. Schmid, T. Ohteki, D. Jarrossay, M. Manz. Nature Immunology, 2007

763 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/11f9004946eeb1bad5156271c0c7198d9c29b102

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Steffen Jung
2. M. Guilliams
3. Florent Ginhoux
4. C. Varol
5. Miriam Merad
6. S. Yona
7. R. Flavell
8. F. Geissmann

Citations in the corpus

• The origin and development of nonlymphoid tissue CD103+ DCs (2009, background): “CDPs, which produce DCs but not monocytes (Naik et al., 2007; Onai et al., 2007b), also gave rise to both CD103+ and CD11b+ cDCs (Fig.”
• Blood monocytes: development, heterogeneity, and relationship with dendritic cells. (2009, background): “However, the controversy on the origin of monocytes and DCs is not completely resolved, and another precursor—the CDP, for common DC precursor—was recently reported to generate cDCs and pDCs, but not monocytes (74, 75).”
• The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Mice that lack either Flt3 or Flt3L have reduced numbers of MDPs, CDPs, and tissue cDCs and pDCs (25, 55, 95).”
• The fate and lifespan of human monocyte subsets in steady state and systemic inflammation (2017, background): “Conversely, DCs and monocytes arise from distinct adult hematopoietic stem cell precursors in the bone marrow (Fogg et al., 2006; Naik et al., 2007; Onai et al., 2007, 2013; Liu et al., 2009; Hettinger et al., 2013; Breton et al., 2015; Lee et al., 2015).”
• Tolerogenic dendritic cells (2016, background): “Both cDCs and pDCs are derived from the common DC progenitors (CDPs) in an Flt3dependent manner [21, 22], but the differentiation of each DC subset is driven by different transcription factors (Fig.”
• Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells (2010, background): “Several papers over the last few years have collectively reported a pathway whereby BM common myeloid progenitors give rise to macrophage and DC precursors, which give rise to common DC precursors (CDPs; Fogg et al., 2006; Naik et al., 2007; Onai et al., 2007; Auffray et al., 2009a; Liu et al., 2009”
• Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development (2008, background): “This CD11c+ population is more mature than the CD11c pro-DCs (Naik et al., 2007; Onai et al., 2007) and has initiated development along the PDC lineage, as judged by the expression of PDC marker Ly-6C and by high recombination frequency in CD11c-Cre mice.”
• Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis (2012, neutral): “Accordingly, classical short-lived Flt3L-dependent DCs are continuously renewed by on-going hematopoiesis in the BM that feeds the periphery with dedicated DC precursors (Naik et al., 2007; Onai et al., 2007; Karsunky et al., 2003; Waskow et al., 2008).”
• Intestinal lamina propria dendritic cell subsets have different origin and functions. (2009, background): “Given the recent progress in our understanding of the origins of splenic DCs (Geissmann et al., 2003; Fogg et al., 2006; Naik et al., 2006; Onai et al., 2007; Varol et al., 2007; Liu et al., 2007; Waskow et al., 2008; Liu et al., 2009), we hence sought to investigate the functional organization of l”