Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
By S. Yona, Ki-Wook Kim, Yochai Wolf, A. Mildner, Diana Varol, Michal Breker, D. Strauss‐Ayali, Sergey V. Viukov, M. Guilliams, A. Misharin and 5 more. Immunity, 2012
3,055 citations recorded by the source corpus.
SUMMARY Mononuclear phagocytes, including monocytes, macrophages and dendritic cells, contribute to tissue integrity, as well as innate and adaptive immune defense. Emerging evidence for labour division indicates that manipulation of these cells could bear therapeutic potential. However, specific ontogenies of individual populations and the overall functional organisation of the cellular network are not well-defined. Here we report a fate mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX3CR1 promoter-driven Cre recombinase expression. We have demonstrated that major tissue resident macrophage populations, including liver Kupffer cells, lung alveolar, splenic and peritoneal macrophages, are established prior to birth and maintain themselves subsequently during adulthood independent of replenishment by blood monocytes. Furthermore, we have established that the short-lived Ly6C+ monocytes constitute obligatory steady state precursors of blood-resident Ly6C− cells and that the abundance of Ly6C+ blood monocytes dynamically controls the circulation life span of their progeny.
Subfields: Immunology, Neurology
View Paper: https://www.semanticscholar.org/paper/ea6a2f0e6590c7f9e9ef7c06b3471015b1bd9196
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Citations in the corpus
- Macrophage heterogeneity in tissues: phenotypic diversity and functions (2014, background): “One of the key functions of yolk sac and fetal liver macrophages is to seed developing organs; recent studies have highlighted the ultimate source of the yolk sac for microglia, Langerhans cells, and many other resident tissue macrophage populations that persist throughout adult life, depending on l”
- Trained immunity: a program of innate immune memory in health and disease (2016, background): “Monocytes are cells with a short half-life in circulation, with recent studies suggesting it to be up to one day (52).”
- Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches (2019, methodology): “To answer this question, we used the tamoxifen-inducible Cx3cr1-Rosa reportermousemodel (26).”
- Microglia development follows a stepwise program to regulate brain homeostasis (2016, background): “Wemight expect to see similar transitions in the resident myeloid cells of other tissues, for example, in Kupffer cells, the resident macrophages of the liver (24, 67).”