Transcription factors in myeloid development: balancing differentiation with transformation

By Frank Rosenbauer, Daniel G. Tenen. Nature reviews. Immunology, 2007

657 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/495193bdd56791783a999810cd19132a268f2fb4

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Citations in the corpus

Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “…common myeloid progenitor; CLP, common lymphoid progenitor; MEP, megakaryocyte/erythroid progenitor; GMP, granulocyte/ macrophage progenitor. inhibition of function of other critical factors, and recruitment of alternative chromatin-modifying enzymes to target loci (Rosenbauer and Tenen, 2007).”
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. (2015, background): “The functions of many of these TFs are highly conserved frommouse to human, and their mutations cause severe lineage abnormalities and blood tumors (Cantor and Orkin, 2002; Rosenbauer and Tenen, 2007).”
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity (2018, background): “These mediators act on HSPCs and myeloid progenitors driving myelopoiesis via inducing transcriptional networks involving transcription factors (TFs) and expression of myeloid-lineage-specific genes (Boettcher and Manz, 2017; Rosenbauer and Tenen, 2007).”
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening. (2017, neutral): “These observations are consistent with the model that myeloid leukemias suffer from a block in terminal differentiation arising as a result of aberrant TF activity (Orkin and Zon, 2008; Rosenbauer and Tenen, 2007).”
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. (2010, background): “Induction of C/EBPb by inflammatory stimuli occurs in most tissues analyzed, and expression of various C/EBP isoforms is differentially induced during macrophage and/ or granulocyte differentiation (Rosenbauer and Tenen, 2007).”
Wishbone identifies bifurcating developmental trajectories from single-cell data (2016, methodology): “This process can be seen as hierarchical tree with the multipotent stem and progenitor cells at the root and the mature differentiated cell types at the bottom with various precursor cells as intermediate cell types [15, 17, 30].”
Transcriptional regulation of macrophage polarization: enabling diversity with identity (2011, background): “A genomic view of macrophage function Myeloid lineage specification and the earliest stages of myeloid differentiation require the activity of Runt-related transcription factor 1 (RUNX1”
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification (2017, background): “, common myeloid progenitors [CMPs]), while the basic-region leucine zipper TF C/EBPa is required for the production of granulocyte/macrophage progenitors (GMPs) from CMPs (Dakic et al., 2005; Rosenbauer and Tenen, 2007).”
Densely interconnected transcriptional circuits control cell states in human hematopoiesis (2011, positive): “These results support the role of chosen regulators in differentiation and are consistent with a broader paradigm in which lineage-speciﬁc promoters can dysregulate key TFs to disrupt differentiation (Rosenbauer and Tenen, 2007; Tomlins et al., 2005).”
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “43,62,63 Runx1, expressed in a subset of microglia during early postnatal forebrain development, regulates myeloid cell proliferation and differentiation.”