Microglial M1/M2 polarization and metabolic states
By Rubén Orihuela, C. McPherson, G. Harry. British Journal of Pharmacology, 2016
1,875 citations recorded by the source corpus.
Subfields: Immunology, Neurology
View Paper: https://www.semanticscholar.org/paper/30ea28a2398ba87ad6539e03f2a01c74311f6ccf
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In Immunology
In Neurology
Citations in the corpus
- Macrophage plasticity, polarization, and function in health and disease (2018, background): “Interestingly, polyamine production has been reported to be a driver of M2 polarization (Biswas & Mantovani, 2012; Covarrubias, Aksoylar, & Horng, 2015; Galvan-Pena & O'Neill, 2014; Lackey & Olefsky, 2016; Orihuela et al., 2016).”
- Microglia Polarization From M1 to M2 in Neurodegenerative Diseases (2022, background): “As influenced by the environment, microglia assume a diversity of phenotypes and have the ability to shift phenotypes to keep tissue homeostasis (Orihuela et al., 2016).”
- Neuroinflammation Induces Neurodegeneration (2016, background): “M1 phenotype is proinflammatory and M2 phenotype is neuroprotective, immunosuppressive and anti-inflammatory and helps in tissue healing process [69].”
- Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms (2020, background): “Upon injury, monocyte infiltrates spinal cord tissue converts into macrophages [129,130].”
- Overview of General and Discriminating Markers of Differential Microglia Phenotypes (2020, background): “Quiescent microglia rely primarily on oxidative phosphorylation for ATP production (Moss and Bates, 2001; Chénais et al., 2002; Orihuela et al., 2016).”
- Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “Whether both microglia and macrophages possess the ability to polarize or it is mainly the property of monocyte derived macrophages is still a matter of debate and needs further elucidation (231) (232) (233) .”