Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-κB, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation1

By S. Manna, A. Mukhopadhyay, Bharat B. Aggarwal. Journal of Immunology, 2000

930 citations recorded by the source corpus.

Subfields: Cancer Research, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e3fc38640406211c3a177e190b5ed71df22d2d3a

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Citations in the corpus

Regulation of inflammation and redox signaling by dietary polyphenols. (2006, background): “Furthermore, in both monocytic U937 cells and alveolar epithelial A549 cells, resveratrol inhibits NF-kB and activator protein-1 (AP-1) activation [45,46].”
Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “Phosphorylation of NF-kB on Ser276 recruits HAT-containing complexes to target promoters (Zhong et al., 2002), while acetylation of NF-kB on multiple lysines affects both its DNA binding and transactivation activity (Chen et al., 2002; Kiernan et al., 2003).”
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase (2004, background): “Resveratrol-induced Sirtuin activity targets the transactivation domain of RelA/p65 Resveratrol was previously shown to inhibit NF-kB activity by disrupting IKK activity (Holmes-McNary and Baldwin, 2000; Manna et al, 2000).”
Anti-Inflammatory Action and Mechanisms of Resveratrol (2021, background): “Resveratrol has been shown to be a double inhibitor of NF-κB signaling, for the reason that treated cells are less responsive to NF-κB signaling and apoptosis initiation induced by TNF-α [51].”
Molecular targets of dietary agents for prevention and therapy of cancer. (2006, background): “Several phytochemicals such as green tea catechins [36], quercetin [37], resveratrol [16], curcumin [38,39], capsaicin [40], oleandrin [41], anethole [26], and beta-lapachone, [42] have been shown to suppress theAP-1 activation process.”
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. (2006, background): “It was reported to have anticancer and antiinflammatory action in vitro [26, 27] and neuroprotective action in vitro [6, 7, 9, 10, 28] and in vivo [10].”
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. (2002, background): “Other clinically available antioxidants reported to have antiinflammatory, antioncogenic, and/or antiatherogenic properties that have been shown to block the activation of NF- B include resveratrol (115, 116), (-)-epicatechin-3-gallate (117), pycnogenol (118), silymarin (119), and curcumin (120).”