Sirtuins: critical regulators at the crossroads between cancer and aging

By L. Saunders, E. Verdin. Oncogene, 2007

606 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Oncology

View Paper: https://www.semanticscholar.org/paper/8669bbf9ccd9b64d3b980b0391cfcf856275a0c3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. E. Seto
2. Xiang-Jiao Yang
3. D. Sinclair
4. L. Guarente

In Geriatrics and Gerontology

1. D. Sinclair
2. E. Seto
3. L. Guarente
4. Xiang-Jiao Yang
5. C. Deng
6. G. Blander
7. Shaday Michán
8. Hyunseok Kim

In Oncology

1. E. Seto
2. D. Sinclair
3. William C. Hahn
4. S. J. Serrano-Gomez
5. L. Guarente
6. S. Alahari
7. Mazvita Maziveyi
8. Xiang-Jiao Yang

Citations in the corpus

• Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis (2010, background): “SIRTs have been demonstrated to play important roles in many physiological and pathophysiological conditions, including metabolism, cell survival, cancer, aging and calorie restriction-mediated longevity of organisms ranging from yeasts to humans [21,22].”
• Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications (2016, background): “SIRT1, 2, 3 and 5 target proteins in the nucleus, cytoplasm and mitochondria for acetylation, while SIRT 4 and 6 regulate ADP ribosylation [84].”
• Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice (2008, positive): “…many nonhistone proteins that are involved in cell growth, apoptosis, neuronal protection, adaptation to caloric restriction, organ metabolism and function, cellular senescence, and tumorigenesis (Baur et al., 2006; Haigis and Guarente, 2006; Saunders and Verdin, 2007; Vaquero et al., 2007).”
• The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth (2008, background): “Moreover, some have argued that mammalian longevity genes that delay agerelated atrophic diseases may conversely predispose humans to a higher incidence of cancer due to their anti-apoptotic function [15].”
• The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, neutral): “DNA damage accumulates with age and defects in DNA repair may lead to phenotypes reminiscent of premature aging (Lombard et al., 2005; Saunders and Verdin, 2007).”
• SIRT3 is a Mitochondrial Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism During Stress (2010, background): “Because cancer is a disease of aging, and sirtuin genes appear to play a role in repair of cellular damage during aging, it is reasonable to propose that sirtuin genes may also have an anticarcinogenic role and function as TSs (Saunders and Verdin, 2007; Wang et al., 2008).”
• HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention (2007, background): “Paradoxically, activators of sirtuins are promising agents against cancer and aging (Saunders and Verdin, 2007).”