Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.

By D. Valenzano, E. Terzibasi, Tyrone Genade, A. Cattaneo, L. Domenici, A. Cellerino. Current Biology, 2006

797 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5000fb53c85c8beac3e35725b301ed03b707cd19

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Johan Auwerx
2. D. Sinclair
3. Joseph A. Baur
4. Brian J. North
5. P. Puigserver
6. C. Cantó
7. L. Guarente
8. Bor Luen Tang

In Molecular Biology

1. Johan Auwerx
2. D. Sinclair
3. Markku Laakso
4. C. Palmeira
5. Brian J. North
6. J. Speakman
7. A. Rolo
8. P. Puigserver

In Physiology

1. Johan Auwerx
2. D. Sinclair
3. Joseph A. Baur
4. C. Palmeira
5. Brian J. North
6. J. Speakman
7. A. Rolo
8. P. Puigserver

Citations in the corpus

• SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “In addition, resveratrol extends life and delays the onset of age-related phenotypes in a short-lived species of fish (Valenzano et al., 2006).”
• Caloric restriction. (2011, background): “, 2004; Greer and Brunet, 2009) and also in a short lived fish (Valenzano et al., 2006) where lifespan was extended by up to 56%.”
• Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan (2008, neutral): “, 2004), and the vertebrate fish Nothobranchius furzeri (Valenzano et al., 2006), although one group has failed to detect a significant effect in worms or flies (Bass et al.”
• Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. (2011, background): “Several groups have reported that resveratrol is able to increase life span in Drosophila (30,31) and Caenorhabditis elegans (30,32,33), and a short-lived species of fish (34), though others have reported that this agent did not increase life span in either of the first two species (35).”
• Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. (2006, background): “…RSV rescued neuronal dysfunction induced by the polyglutamine tracts in the Huntington protein in C. elegans (Parker et al., 2005) and significantly delayed the age-dependent decay of locomotor activity and cognitive performances in the short-lived vertebrate, N. furzeri (Valenzano et al., 2006).”