Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions

By T. Kusch, L. Florens, W. H. MacDonald, S. Swanson, R. Glaser, John R. Yates III, S. M. Abmayr, M. Washburn, Jerry L. Workman. Science, 2004

719 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e34fcc36f46548302fd0ad24b8dc430cc611410e

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In Molecular Biology

1. W. Gu
2. John R. Yates III
3. Steven Henikoff
4. S. Polo
5. Yi Tang
6. G. Iliakis
7. Wenqi Wu
8. A. Kinner

Citations in the corpus

• Histone acetyltransferase complexes: one size doesn't fit all (2007, background): “In turn, these associations allow them to carry out specialized functions, which the enzyme would not be capable of on its ow”
• Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. (2011, background): “Tip60 also acetylates H2AX, which promotes H2AX eviction from damaged chromatin, as shown in both Drosophila and mammalian cells (Kusch et al. 2004; Ikura et al. 2007).”
• The biology of chromatin remodeling complexes. (2009, background): “Z (called H2Av), and dTIP60 exchanges phospho-H2Av for unmodified histone H2Av in a manner facilitated by the acetylation of phospho-H2Av (92).”
• Regulation of nucleosome dynamics by histone modifications (2013, positive): “Z.X acetylation by Tip60 complex, increasing the exchange of histone γ H2A.”
• Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. (2006, background): “Nevertheless, these defects were not obviously detected in the p53-6KR mouse embryonic fibroblasts cells (Feng et al., 2005; Krummel et al., 2005 ), raising the notion that functional redundancy or additional coactivators are involved in p53 activation.”
• Chromatin challenges during DNA replication and repair. (2007, neutral): “One of the most intensively studied histone modifica-tions associated with DSB repair is the phosphorylation of histone H2AX variants (H2AX in mammals, H2Av in Drosophila , and H2A in yeast).”
• The γ‐H2A.X: Is it just a surrogate marker of double‐strand breaks or much more? (2008, neutral): “X [Downs et al., 2004; Kusch et al., 2004; Morrison et al., 2004; van Attikum et al., 2004; Stucki et al., 2005]. c-H2A.”
• γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin (2008, background): “Work in yeast and Drosophila further indicates that the above events of protein accumulation and modification in response to DSBs may be further enhanced or facilitated by g-H2AX-mediated recruitment of chromatin remodeling complexes (59–62,87,88).”
• Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. (2005, background): “For instance, the Eaf3 ortholog MRG15 in Drosophila and mice is important for proper embryonic development (Kusch et al., 2004; Tominaga et al., 2005).”