The γ‐H2A.X: Is it just a surrogate marker of double‐strand breaks or much more?

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NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “This phosphorylation is required for DSB signalling and is thought to act as a beacon to recruit and retain DNA repair proteins to the DSB site [206,207].”
DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. (2008, methodology): “To support the hypothesis that Ag NPs can cause DNA damage, we utilized the expression of Rad51, a key double strand break repair protein involved in non-homologous end join repair, and also histone H2AX which is phophorylated at serine 139 at the site of DNA double strand break (Ismail and Hendzel,”
γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin (2008, background): “Thus, g-H2AX has the potential of developing to a useful predictor of cellular radiosensitivity to killing and may find application in the clinic during treatment of human tumors with ionizing radiation, in the evaluation of interindividual variations in radiosensitivity (141,142), in the analysis o”