Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis.

By Yi Tang, Jianyuan Luo, Wenzhu Zhang, W. Gu. Molecules and Cells, 2006

741 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/802114e15a8e7637229c15822b38cdc9392152ae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. W. Gu
2. Jiandong Chen
3. Xiang-Jiao Yang
4. E. Seto
5. Karen H. Vousden
6. Carol Prives
7. Yingming Zhao
8. Yi Tang

In Oncology

1. W. Gu
2. Jiandong Chen
3. E. Seto
4. Karen H. Vousden
5. Yingming Zhao
6. Carol Prives
7. N. Kon
8. Yi Tang

Citations in the corpus

• HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention (2007, background): “For example, p300, PCAF and two members of the MYST family acetylate p53 (Gu and Roeder, 1997; Sakaguchi et al., 1998; Liu et al., 1999; Sykes et al., 2006; Tang et al., 2006).”
• The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. (2016, background): “Acetylation of K120 in the DNAbinding domain by acetylases Tip60 or hMOF specifically promotes apoptosis (Sykes et al. 2006; Tang et al. 2006).”
• Acetylation is indispensable for p53 activation. (2008, methodology): “Following our early findings of C terminus p53 acetylation, we and others recently showed that p53 is also acetylated by Tip60/hMOF at residue K120 within the DNA-binding domain (Tang et al., 2006; Sykes et al., 2006).”
• Lysine Propionylation and Butyrylation Are Novel Post-translational Modifications in Histones*S (2007, background): “Given the fact that CBP/p300 are the acetyltransferases for p53 and that they have enzymatic activities for lysine propionylation and butyrylation in histones, we tested whether the HATs could catalyze similar reactions in p53.”
• Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence (2012, positive): “We and others recently showed that p53 is acetylated at K120 by Tip60/MOF (Sykes et al., 2006; Tang et al., 2006; Li et al., 2009), whereas K164 is acetylated by CBP and p300, but not Tip60/MOF (Tang et al.”
• Blinded by the Light: The Growing Complexity of p53. (2009, background): “transfereases (HATs)—Tip60 (Tang et al., 2006) and hMOF (Sykes et al.”
• Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “Moreover, its acetylation lies at the nexus of apoptotic and cell-cycle control (Sykes et al., 2006; Tang et al., 2006), so it will be interesting to determine if K117R mutant mice display more dramatic phenotypes.”