Histone acetyltransferase complexes: one size doesn't fit all

By Kenneth K. Lee, Jerry L. Workman. Nature reviews. Molecular cell biology, 2007

1,124 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5b114b0543464eaf0b67b5d5a34e79c2b1e39bd5

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Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (2010, background): “Instead, starting with the observation that Sgf29, which we identified as a H3K4me3 interactor, has a double Tudor domain (Lee and Workman, 2007) and given Cell 142, 967–980, September 17, 2010 ª2010 Elsevier Inc. 977 the fact that Tudor domains can bind methylated lysines (Huang et al., 2006), we…”
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention (2007, background): “…5 (Gcn5)-related N-acetyltransferases (GNATs), p300/CBP and MYST proteins (reviewed by Sterner and Berger, 2000; Roth et al., 2001; Lee and Workman, 2007). p300 (adenoviral E1A-associated protein of 300 kDa) and CBP (CREB-binding protein) form a pair of paralogous transcriptional…”
Histone Deacetylase Inhibitors as Anticancer Drugs (2017, background): “However, they do not contain true consensus HAT domains and therefore represent an “orphan class” of HAT enzymes [26].”
The DNA damage response: ten years after. (2007, background): “Many studies have identified roles for Kap1, a chromatin global regulator, and the INO80, NuA4, SWI/SNF, and RSC chromatin remodeling complexes in responding to DNA damage (Lee and Workman, 2007).”
Chemical Phylogenetics of Histone Deacetylases (2010, background): “As components of chromatin-modifying enzyme complexes, HDACs target the N-terminal tails of histone proteins and thus affect chromatin conformation and gene-specific transcriptio”
Influence of Metabolism on Epigenetics and Disease (2013, positive): “Acetyl-CoA is also the substrate used by histone acetyl transferase (HAT) enzymes to modify histone tails as an integral determinant of the epigenetic state of chromatin in eukaryotic cells (Figure 1) (Lee and Workman, 2007; Shahbazian and Grunstein, 2007).”
Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “Similar consideration should also be made for GCN5, PCAF, and the MYST family of acetyltransferases, all of which form multiprotein complexes (Lee and Workman, 2007).”
Distinct roles of GCN5/PCAF‐mediated H3K9ac and CBP/p300‐mediated H3K18/27ac in nuclear receptor transactivation (2011, background): “In contrast, the yeast NuA3 complex preferentially acetylates H3K14 (Lee and Workman, 2007).”
Modification of enhancer chromatin: what, how and why? (2013, background): “Subsequent investigations identified many distinct HATs with coactivator activity and showed that TF-dependent transcriptional activation from chromatinized templates is strongly stimulated by histone acetylation (Brown et al., 2000; Lee and Workman, 2007).”