microRNAs join the p53 network — another piece in the tumour-suppression puzzle

By Lin He, Xingyue He, Scott W. Lowe, Gregory J. Hannon. Nature Reviews. Cancer, 2007

600 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e3242e3a55db9f27c17b08d196f63cd1b8371c1c

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Citations in the corpus

miR-19 is a key oncogenic component of mir-17-92. (2009, background): “Multiple miRNAs were subsequently identified to promote or suppress oncogenesis, presumably by modulating gene expression in the oncogenic and tumor suppressor networks (He et al. 2005, 2007a; Johnson et al. 2005; Kumar et al. 2008; Kota et al. 2009).”
MicroRNAs and cancer: short RNAs go a long way. (2009, background): “These studies have focused on the miRNAs regulated by p53, a tumor suppressor gene that is frequently inactivated in human cancers (reviewed in He et al., 2007 and references therein).”
A microRNA DNA methylation signature for human cancer metastasis (2008, result): “Our data also corroborate the findings of recent studies showing that miR-34 activation recapitulates tumor suppressor events associated with p53 activity (28, 29) and that the downregulation of miR-148a, miR-9-2, and miR-34 is part of a unique 20-miRNA metastasis signature in liver tumors (30).”
Senescence of activated stellate cells limits liver fibrosis (2008, background): “p53 promotes senescence by transactivating genes that inhibit proliferation, including the p21/Cip1/Waf1 cyclin-dependent kinase inhibitor and miR-34 class of microRNAs (He et al., 2007).”
Therapeutic delivery of miR-26a inhibits cancer cell proliferation and induces tumor-specific apoptosis (2009, positive): “Additionally, miRNAs provide critical functions downstream of classic oncogenic and tumor suppressor signaling pathways such as those controlled by Myc and p53 (Chang et al., 2008; He et al., 2007b; O'Donnell et al., 2005).”
MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008, background): “By negatively regulating their mRNA targets to either degradation or translational repression, they can act as both tumor suppressors and oncogenes (19, 27, 41, 43).”
An overview of microRNAs (2015, neutral): “miR-34 is another notable cancer-associated miRNA family[176].”
The microcosmos of cancer (2012, background): “One of the best-studied classes is the miR-34 family ( Table 1 ), which represses genes that can promote proliferation and apoptosis — plausible targets in a p53-mediated tumour-suppressor respons”
p53 represses c-Myc through induction of the tumor suppressor miR-145 (2009, background): “To date, the miR-34 family are the only known miRNAs that are directly regulated by p53 (27).”
ROS and p53: a versatile partnership. (2008, background): “, myc [17], hCAS/CSE1L [18], Hzf [19], and miR-34 [20]), can play a role in selective transactivation of p53 target genes that leads to different cellular outcomes.”
MicroRNAs in human cancer. (2013, background): “TP53regulated, ectopically expressed miR-34 induced cell cycle arrest in both primary and tumor derived cell lines, downregulating genes promoting cell cycle progression (reviewed in [ 58 ] ).”
Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology (2008, background): “DNA damage–related pathological processes including carcinogenesis (He et al., 2007; Kroll, 2007; Pinkston-Gosse and Kenyon, 2007; Poulin et al., 2004; Sherwood et al., 2005; van Haaften et al., 2004a), aging (Antebi, 2007; Brys et al.”
MicroRNA and cancer (2012, background): “The miR-34 family and its variety of functions has become an intensely studied area with a large number of publications relating to this important tumour suppressor miRNA family (He et al., 2007b; Hermeking, 2009).”
MicroRNAs — the micro steering wheel of tumour metastases (2009, background): “Accordingly, numerousgenetic studies allowed the identification of miRNA abnormalities in human cancer by dissecting their transcriptional regulator”