A microRNA DNA methylation signature for human cancer metastasis

By A. Lujambio, George A. Calin, A. Villanueva, S. Ropero, M. Sanchez-Cespedes, D. Blanco, L. Montuenga, Simona Rossi, M. Nicoloso, W. Faller and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,128 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/7f0f076981bb94dfd93f75d09bff9cb1786827ac

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Citations in the corpus

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer (2011, background): “The mechanisms by which ncRNA expression is altered in cancers are similar to those for protein coding genes, and include epigenetic mechanisms (Lujambio et al., 2007, 2008; Saito et al., 2010).”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “58 ), and the constitutive activation of signalling that promotes invasiveness and metatstatic activitie”
MicroRNAs — the micro steering wheel of tumour metastases (2009, background): “Additionally, a study by Lujambio and colleagues from the Esteller group examined epigenetic changes of miRNA genes in tumours and identified an miRNA hypermethylation profile characteristic of human metastasi”
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis (2010, background): “A recent study showed that miR-9-encoding gene promoters, as well as the promoters of genes encoding two other miRNAs (miR-34b/c and miR-148a), were methylated in a relatively large fraction of primary tumours present in patients with lymph node metastases; in contrast, only a small fraction of prim”
miR-34 – a microRNA replacement therapy is headed to the clinic (2012, background): “Hypermethylation of the miR-34 promoters is another mechanism that can lead to reduced levels of endogenous miR34 family members (Lodygin et al., 2008; Lujambio et al., 2008; Vogt et al., 2011).”
DNA Methylation and Its Basic Function (2013, background): “Like other sequences within the genome, DNA methylation can regulate the expression of miRNAs (Han et al, 2007; Lujambio et al, 2008).”
A Pleiotropically Acting microRNA, miR-31, Inhibits Breast Cancer Metastasis (2009, neutral): “…that function as classical oncogenes or tumor suppressor genes (Ventura and Jacks, 2009), as well as a limited number that act at late stages of tumor progression (Ma et al., 2007; Tavazoie et al., 2008; Huang et al., 2008; Asan- gani et al., 2008; Zhu et al., 2008; Lujambio et al., 2008).”
Aberrant epigenetic landscape in cancer: how cellular identity goes awry. (2010, neutral): “, 2010), glioblastomas (Martinez et al., 2009), astrocytomas (Wu et al.”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “19 ), or depends on the methylation of their promoter sequence”