MicroRNAs and cancer: short RNAs go a long way.

By A. Ventura, T. Jacks. Cell, 2009

944 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/502d495e48837c4af253d3bc0bf7117ef9e1cf8c

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Citations in the corpus

Development of microRNA therapeutics is coming of age (2014, neutral): “…metabolic disorders, suggesting that miRNAs could serve as targets for therapeutic intervention (van Rooij et al , 2007; Gottwein & Cullen, 2008; Ventura & Jacks, 2009; Najafi-Shoushtari et al , 2010; Rayner et al , 2010; Grueter et al , 2012; van Rooij, 2012; van Rooij & Olson, 2012; Rottiers…”
microRNAs in cancer (2013, background): “Overexpression of the cluster is observed in a variety of human cancers, including small cell lung cancer, colon cancer, neuroblastoma, medulloblastoma, gastric cancer, and osteosarcoma (60).”
When mutants gain new powers: news from the mutant p53 field (2009, background): “Moreover, with the appreciation of the importance of post-transcriptional gene regulation in tumorigenesis, and, specifically, the key roles of microRNAs in cancer developmen”
Modulation of K-ras-dependent lung tumorigenesis by microRNA-21 (2010, positive): “MiR-21 , suggesting that miR-21 inhibition could be of therapeutic c. in human cancer pathogenesis (Ventura and Jacks, 2009).”
Therapeutic delivery of miR-26a inhibits cancer cell proliferation and induces tumor-specific apoptosis (2009, positive): “Finally, functional studies have directly documented the potent pro- and antitumorigenic activity of specific miRNAs both in vitro and in vivo (Ventura and Jacks, 2009).”
MicroRNA control of signal transduction (2010, background): “Strikingly, expression profiling experiments show a global downregulation of miRNAs in tumour samples compared with normal tissue”
An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation (2009, neutral): “MicroRNAs play critical roles in many biological processes including cancer by directly interacting with specific messenger RNAs (mRNAs) through base pairing and then inhibiting expression of the target genes through a variety of molecular mechanisms (Bartel, 2009; Ventura and Jacks, 2009).”
miRNAs in human cancer (2010, background): “The observed effects of miRNA mis-expression on tumour initiation, maintenance or metastasis can be explained by the mRNA targets and pathways they regulate, which include known tumour suppressors and oncogenes (reviewed in [11]).”
Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling (2011, background): “Similarly to oncogenes, such as HER2, whose over-expression defines a subset of breast tumors, miRNAs have also been suggested to act as oncogenes (or tumor suppressors) contributing to distinct tumor characteristics (6, 7, 8, 9).”
A Pleiotropically Acting microRNA, miR-31, Inhibits Breast Cancer Metastasis (2009, positive): “In addition, miRNAs have been identified that function as classical oncogenes or tumor suppressor genes (Ventura and Jacks, 2009), as well as a limited number that act at late stages of tumor progression (Ma et al.”
A MicroRNA targeting dicer for metastasis control. (2010, background): “…between miR-103/107 and Dicer Levels in Cancer Cell Lines At this point, we were intrigued by the analogy between the effects of miR-103/107 on Dicer function and the hampered maturation of multiple miRNAs observed in human tumors (Lu et al., 2005; Ozen et al., 2008; Ventura and Jacks, 2009).”
Silencing of microRNA families by seed-targeting tiny LNAs (2011, background): “Furthermore, miRNA perturbations are prevalent in and are strongly associated with the development of human diseases, such as viral infections, cancer, cardiovascular and muscle disease”