ROS and p53: a versatile partnership.

By Bin Liu, Yumin Chen, D. S. St. Clair. Free Radical Biology & Medicine, 2008

806 citations recorded by the source corpus.

Subfields: Biotechnology, Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/4449a92c0d4332b9f32b2b013becf96d4f8d8f95

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. Carol Prives
2. Karen H. Vousden

In Cancer Research

1. Subash C. Gupta
2. Bharat B. Aggarwal
3. Carol Prives
4. Karen H. Vousden
5. Simone Reuter

In Oncology

1. Carol Prives
2. Karen H. Vousden
3. M. Guo
4. Haolan Wang
5. Yongheng Chen
6. Hudie Wei
7. Subash C. Gupta
8. Bharat B. Aggarwal

Citations in the corpus

• Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “Fifth, ROS controls the expression of various tumor suppressor genes, including p53 (47, 190, 275).”
• Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “In addition, ROS induce both the activation and synthesis of AP-1, a regulator of cell growth, proliferation, and apoptosis [138,139], and transcription factors such as STAT3, HIF-1α, and p53 [118,140,141].”
• Regulation of superoxide dismutase genes: implications in disease. (2009, background): “The compartmentalization and control of SODs at both the expression and the activity level contribute to the level of SOD and consequent localized ROS level [21,22].”
• Blinded by the Light: The Growing Complexity of p53. (2009, background): “antioxidants by decreasing the levels of intracellular reactive oxygen species (Liu et al., 2008; Sablina et al., 2005).”
• Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution (2024, background): “In this mechanism, ROS act as a central player, providing a dynamic balance between Nrf2 activation and its inhibition by Keap1 (Figure 7) [71].”
• Targeting p53 pathways: mechanisms, structures and advances in therapy (2023, background): “111,112 The regulation of ROS by p53 also has a dual function.”
• ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases (2016, background): “Receptor-dependent or nondependent tyrosine kinases, AMP-activated protein kinases, adaptor protein p66SHC, and transcription factors as FOXO (forkhead homeobox type O), Nrf2 (nuclear factor E2-related factor 2), p53 (tumor suppressor 53), NFκB (nuclear factor kappa B), AP-1 (activator protein-1), H”