MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

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MicroRNAs in development and disease. (2011, background): “It targets the metalloproteinase (MMP) inhibitors, reversion-inducing-cysteine-rich protein with kazal motifs (RECK) and tissue inhibitor of metalloproteinase-3 (TIMP3) and, thus, activates MMPs and facilitates cell motility and metastasis both in vitro and in vivo (192).”
MicroRNAs — the micro steering wheel of tumour metastases (2009, methodology): “In fact, miR-21 was found to stimulate cell invasion and metastasis in different tumour models (breast cancer, colon cancer and gliomas) using similar in vitro and in vivo assay”
miR-21: a small multi-faceted RNA (2008, methodology): “Several computational algorithms predict hundreds of mRNAs as possible targets for miR-21 [55–57 [49, 53] and proteomics [58], each with certain advantages and flaws, have been used after cell treatments with anti-miR-21.”