The microcosmos of cancer

By A. Lujambio, Scott W. Lowe. Nature, 2012

1,122 citations recorded by the source corpus.

The discovery of microRNAs (miRNAs) almost two decades ago established a new paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have been linked to virtually all known physiological and pathological processes, including cancer. In the same way as certain key protein-coding genes, miRNAs can be deregulated in cancer, in which they can function as a group to mark differentiation states or individually as bona fide oncogenes or tumour suppressors. Importantly, miRNA biology can be harnessed experimentally to investigate cancer phenotypes or used therapeutically as a target for drugs or as the drug itself.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1472c5f58ac2ae7006df8a91eb032f46d4bcdd5a

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Citations in the corpus

CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set (2012, background): “miR-18a has previously been shown to be part of a polycistronic oncogenic microRNA cluster, which includes 6 consecutive mature microRNAs, miR-17, -18a, -19a, -19b, -20a, and -92a co-expressed as a single primary transcript (25, 34).”
Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. (2014, background): “Nonetheless, during cell differentiation and in the context of malignant transformation, expression of coding and non-coding RNA can change dramatically (Rhodes and Chinnaiyan, 2005; Lujambio and Lowe, 2012).”
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “Numerous studies have documented that miRNAs have important regulatory functions in biological processes that represent the hallmarks of cancer, such as proliferation, apoptosis, invasion, and metastasis (14).”
Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “Both tumor environmental cues and cell-intrinsic alterations contribute to these epigenetic changes, inducing adaptations by cancer cells that allow successful invasion of the stroma, entry and survival in lymphatic or blood vessels, spread to and colonization of distant/different organs, as well as”
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas (2019, background): “Differential microRNA expression was also compared, as p53 is known to transcriptionally target a number of specific miRNAs (Hermeking, 2012; Lujambio and Lowe, 2012).”
Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (2016, background): “MicroRNAs (miRNAs) are highly conserved, small noncoding RNA molecules, which posttranscriptionally regulate gene expression via inhibition of mRNA translation or inducing degradation of target mRNAs [162].”