Oxidative DNA damage and disease: induction, repair and significance.

By M. Evans, M. Dizdaroglu, M. Cooke. Mutation research, 2004

1,319 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e04da991586f9f9bf0c54b6eb315904ca5b693ec

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Citations in the corpus

Regulation of superoxide dismutase genes: implications in disease. (2009, background): “Oxidative stress caused by the imbalance between reactive oxygen species (ROS) or reactive nitrogen species (RNS) and biological antioxidant system can lead to modification of macromolecules such as DNA, lipid and protein [1-3].”
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “Oxidative damage to both nuclear and mitochondrial DNA has detrimental effects, leading to uncontrolled cell proliferation or accelerated cell death (64).”
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? (2004, background): “…in levels of 8OHdG and other DNA base damage products have been observed in many studies on diseased human material (reviewed by Halliwell, 2000c; Evans et al., 2003), although (as with the isoprostanes) effects of dietary antioxidant supplementation on levels of 8OHdG or other base damage…”
Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? (2016, background): “Imperfect repair of such DNA damage can lead to mutations, arrest of cell growth, or apoptosis [36].”
Oxidative stress and neurodegeneration: where are we now? (2006, background): “Hydroxyl radical also attacks other bases and the deoxyribose sugar in DNA, producing massive damage (Evans et al. 2004).”
Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, background): “stress induced by acute exposure to ozone, accompanied by altered lung functioning [16].”
The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults (2016, background): “ROS can be generated at elevated rates under normal aging, as well as in acute or chronic pathophysiological conditions [4–6].”
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, background): “So far over 80 different oxidized bases in DNA exposed to oxidant factors, such as H2O2 and singlet oxygen, have been identified [45, 46].”
Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “The 8-OHdG lesion is preferentially repaired by the base excision repair (BER) enzymes, including 8-oxo-guanine DNA glycosylase (OGG1), nei-like glycosylase 1 (NEIL1), apurinic/apyrimidinic (AP) endonuclease 1 (APE1), and MutY homologue (MUTYH) (Evans et al. 2004).”
Mechanisms of nanotoxicity: Generation of reactive oxygen species (2014, background): “The damage in cell function and development includes oxidative modification of proteins to generate protein radicals [45], initiation of lipid peroxidation [46e48], DNA-strand breaks, modification to nucleic acids [49], modulation of gene expression through activation of redox-sensitive transcriptio”
Reactive Oxygen Species, Oxidative Damage, and Antioxidative Defense Mechanism in Plants under Stressful Conditions (2012, neutral): “ROS abstract hydrogen atom from the C4′ position of deoxyribose, leading to generation of a deoxyribose radical that further reacts to produce DNA strand breakage [109].”