The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

By M. Nita, Andrzej Grzybowski. Oxidative Medicine and Cellular Longevity, 2016

1,312 citations recorded by the source corpus.

The reactive oxygen species (ROS) form under normal physiological conditions and may have both beneficial and harmful role. We search the literature and current knowledge in the aspect of ROS participation in the pathogenesis of anterior and posterior eye segment diseases in adults. ROS take part in the pathogenesis of keratoconus, Fuchs endothelial corneal dystrophy, and granular corneal dystrophy type 2, stimulating apoptosis of corneal cells. ROS play a role in the pathogenesis of glaucoma stimulating apoptotic and inflammatory pathways on the level of the trabecular meshwork and promoting retinal ganglion cells apoptosis and glial dysfunction in the posterior eye segment. ROS play a role in the pathogenesis of Leber's hereditary optic neuropathy and traumatic optic neuropathy. ROS induce apoptosis of human lens epithelial cells. ROS promote apoptosis of vascular and neuronal cells and stimulate inflammation and pathological angiogenesis in the course of diabetic retinopathy. ROS are associated with the pathophysiological parainflammation and autophagy process in the course of the age-related macular degeneration.

Subfields: Molecular Biology, Neurology, Ophthalmology

View Paper: https://www.semanticscholar.org/paper/e2fb8a7052cd4e41ce9eee48d172a1adb926bf60

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Citations in the corpus

• Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases (2018, background): “The production of reactive species via PG synthesis pathway contributes significantly to the overall reactive species pool in both pathological and normal states, especially during aging (Nita and Grzybowski, 2016).”
• Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases (2023, background): “Hydroxyl radicals directly target the different components of DNA such as deoxyribose sugar backbone, pyrimidine and purine bases, and result from single and double-stranded breaks in the DNA (Nita and Grzybowski, 2016).”
• Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “alters genomic stability and impairs DNA repair pathways [52].”