Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?

By S. Biswas. Oxidative Medicine and Cellular Longevity, 2016

1,106 citations recorded by the source corpus.

Oxidative stress has been implicated in many chronic diseases. However, antioxidant trials are so far largely unsuccessful as a preventive or curative measure. Chronic low-grade inflammatory process, on the other hand, plays a central role in the pathogenesis of a number of chronic diseases. Oxidative stress and inflammation are closely related pathophysiological processes, one of which can be easily induced by another. Thus, both processes are simultaneously found in many pathological conditions. Therefore, the failure of antioxidant trials might result from failure to select appropriate agents that specifically target both inflammation and oxidative stress or failure to use both antioxidants and anti-inflammatory agents simultaneously or use of nonselective agents that block some of the oxidative and/or inflammatory pathways but exaggerate the others. To examine whether the interdependence between oxidative stress and inflammation can explain the antioxidant paradox we discussed in the present review the basic aspects of oxidative stress and inflammation and their relationship and dependence.

Subfields: Biochemistry, Clinical Biochemistry, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/c0dd863d8e2e068d8e2dc20d4799126592382c5b

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In Biochemistry

1. D. Kalman
2. Nur Samsu
3. S. Hewlings

In Clinical Biochemistry

1. D. Kalman
2. Nur Samsu
3. S. Hewlings

In Nutrition and Dietetics

1. D. Kalman
2. Nur Samsu
3. S. Hewlings

Citations in the corpus

• Phenolic Compounds in Honey and Their Associated Health Benefits: A Review (2018, background): “Both processes have often been found simultaneously in subjects with diabetes, cancer, cardiovascular, neurodegenerative disorders, and many other disease situations [53].”
• Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases (2018, background): “Other pro-inflammatory proteins such as vascular cell adhesion molecule 1 (VCAM-1), P- and Eselectin, and intercellular adhesion molecule 1 (ICAM-1), are all enhanced during aging (Biswas, 2016).”
• Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019, background): “Oxidative stress also plays an important role in determining and maintaining this lowgrade inflammation, which, in turn contributes to oxidative stress (61, 62).”
• Curcumin: A Review of Its’ Effects on Human Health (2017, background): “oxidative stress, which demonstrates the relationship between oxidative stress and inflammation [28].”
• Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment (2021, background): “On the other hand, inflammation as a primary disorder can cause oxidative stress as a secondary disorder, which can further increase inflammation [67].”