Oxidative stress and neurodegeneration: where are we now?

By Barry Halliwell. Journal of Neurochemistry, 2006

2,654 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/a8ab4208ecec4d8a846bb42602b6205c7d82e5df

How researchers see this paper

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In Molecular Biology

1. Kamrun Nahar
2. M. Hasanuzzaman
3. Mahabub Alam
4. M. Fujita
5. Wook Kim
6. P. Whitton
7. J. M. May
8. D. E. Rao

In Neurology

1. P. Whitton
2. J. M. May
3. D. E. Rao
4. S. Gandhi
5. Michael Maes
6. A. Abramov
7. Kamrun Nahar
8. S. Biswas

In Physiology

1. P. Whitton
2. J. M. May
3. D. E. Rao
4. S. Gandhi
5. A. Abramov
6. Kamrun Nahar
7. S. Biswas
8. F. Harrison

Citations in the corpus

• Reactive oxygen species in plants: their generation, signal transduction, and scavenging mechanisms (2011, background): “Metabolic pathways in the univalent reduction of molecular oxygen (O2) to water (H2O) leading to generation of various intermediate reactive oxygen species (ROS) in plants (Halliwell and Gutteridge, 2000; Dismukes et al., 2001; Mittler et al., 2004; Scandalios, 2005; Halliwell, 2006).”
• Oxidative Stress, Prooxidants, and Antioxidants: The Interplay (2014, background): “This results in the oxidative stress phenomenon [156].”
• Inflammation as a causative factor in the aetiology of Parkinson's disease (2007, background): “All tissues can be damaged as a result of oxidative stress; however, the brain appears to be particularly susceptible, no doubt due to its heavy oxygen demands (Halliwell, 2001, 2006).”
• The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression (2009, background): “The brain and the nervous system are prone to oxidative stress (OS) since they are inadequately equipped with antioxidant defense systems to prevent oxidative damage (Halliwell 2006).”
• Vitamin C Function in the Brain: Vital Role of the Ascorbate Transporter (SVCT2) (2009, background): “Oxidative stress in the brain with a focus on neurodegenerative diseases has been extensively reviewed [150], so only aspects relevant to ascorbate will be considered here.”
• Physiological, Biochemical, and Molecular Mechanisms of Heat Stress Tolerance in Plants (2013, background): “Continual heat stress causes the ROS accumulation at the plasma membrane outer surface which can cause membrane depolarization [105], activation of Ca-induced RBOHD (the ROS-producing enzyme RBOHD located at the plasma membrane).”
• Complexity of dopamine metabolism (2013, background): “Due to ROS overload, injurious effects such as lipid oxidation, uncoupling of the electron transport chain or DNA damage occur, which finally leads to cell death [181-184].”
• Mechanism of Oxidative Stress in Neurodegeneration (2012, background): “Neurons and astrocytes, the two major types of brain cells, are largely responsible for the brain’s massive consumption of O2 and glucose; indeed, the brain represents only ∼2% of the total body weight and yet accounts for more than 20% of the total consumption of oxygen [2].”
• Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, background): “It has been well-established that, in neurodegenerative disease, neurodegeneration can occur as the result of oxidative stress, the imbalance of antioxidant and prooxidant levels [422].”