Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging

By Saverio Marchi, C. Giorgi, Jan M. Suski, Chiara Agnoletto, Angela Bononi, M. Bonora, Elena De Marchi, S. Missiroli, S. Patergnani, Federica Poletti and 4 more. Journal of signal transduction, 2011

632 citations recorded by the source corpus.

Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS function as “redox messengers” in intracellular signalling and regulation, whereas excess ROS induce cell death by promoting the intrinsic apoptotic pathway. Recent work has pointed to a further role of ROS in activation of autophagy and their importance in the regulation of aging. This review will focus on mitochondria as producers and targets of ROS and will summarize different proteins that modulate the redox state of the cell. Moreover, the involvement of ROS and mitochondria in different molecular pathways controlling lifespan will be reported, pointing out the role of ROS as a “balance of power,” directing the cell towards life or death.

Subfields: Aging, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0b7aba87da9aa8482709262812a28c42f864b184

Citations in the corpus

• Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances (2025, neutral): “108,109 112 Cadmium, a promotor of excessive ROS production, induces mitophagy through the PINK1/Parkin pathway, while cadmium-induced mitophagy could be reversed after ROS clearance with ROS scavenger.”