Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis.

By G. Bjelakovic, D. Nikolova, R. Simonetti, C. Gluud. The Lancet, 2004

632 citations recorded by the source corpus.

Subfields: Biochemistry, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/def29c5a72f80792571d07c008cb3bb76bd6b9aa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. M. Rayman
2. Michael Ristow

In Nutrition and Dietetics

1. M. Rayman
2. Michael Ristow

Citations in the corpus

• Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. (2007, background): “10) associated with the taking of these supplements.(54) A randomized controlled trial of the Women’s Health Study found no effect of supplementation with 600 IU/d of vitamin E on total mortality.”
• The changing faces of glutathione, a cellular protagonist. (2003, background): “Toyokuni Iron and thiol compounds in carcinogenesis However, thus far, antioxidant supplementation has not officially been recommended based on the results of epidemiological studies (Bjelakovic et al., 2004, 2007).”
• How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). (2010, background): “More importantly, a number of studies suggests that antioxidants may promote cancer in humans (Bjelakovic et al., 2004; Bairati et al., 2005; Hercberg et al., 2007; Bardia et al., 2008; Lawenda et al., 2008; Myung et al., 2010).”
• Role of ROS and Nutritional Antioxidants in Human Diseases (2018, background): “Inappropriate antioxidant application can be harmful by scavenging of physiological ROS (Bjelakovic et al., 2004; Poljsak et al., 2013).”
• Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. (2008, result): “[46] Bjelakovic, G.”
• Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality (2005, neutral): “A recent meta-analysis that examined the effects of antioxidants, not specifically vitamin E, in preventing cancer noted a possible increase in all-cause mortality (54).”
• Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “exogenous vitamin E and other antioxidants have not been shown to prevent gastrointestinal cancers (32).”
• American Cancer Society guidelines on nutrition and physical activity for cancer prevention (2002, neutral): “in cancer risk from these supplements; indeed, some have seen an increased risk of cancer among those taking supplements.(125,333) (See also ‘‘Beta-Carotene,’’ ‘‘Lycopene,’’ ‘‘Vitamin E,’’ and ‘‘Supplements.”
• Food-chain selenium and human health: emphasis on intake (2008, neutral): “Mortality (RDA/RNI) After adjustment for confounding factors, low plasma Se concentration was significantly associated with higher mortality in the 9-year longitudinal EVA study of 1389 elderly French individuals of mean baseline plasma Se 87mg/l((82)) Low serum Se was associated with a significantl”
• Selenium in cancer prevention: a review of the evidence and mechanism of action (2005, background): “A recent systematic review and meta-analysis of antioxidant supplements for the prevention of gastrointestinal cancers has assessed the evidence for an effect of Se (Bjelakovic et al. 2004).”
• Systematic Review and Meta-analysis Supplements for Primary and Secondary Prevention: Mortality in Randomized Trials of Antioxidant (2009, neutral): “We found that antioxidant supplements, with the potential exception of selenium, were without significant effects on gastrointestinal cancers and increased all-cause mortality.(14,15) We did not examine the effect of antioxidant supplements on all-cause mortality in all randomized prevention trials.”