Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

By E. Miller, R. Pastor-Barriuso, D. Dalal, R. Riemersma, L. Appel, Eliseo Guallar. Annals of Internal Medicine, 2005

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Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline (2007, background): “thermore, a large meta-analysis of studies with vitamin E has shown that high-dosage (£400 IU/day) vitamin E supplements may increase all cause mortality (I) [179].”
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases (2018, background): “One meta-analysis suggested that doses of >800 IU/day were associated with increased all-cause mortality.((186)) However, this metaanalysis has been criticized because several studies with low mortality were excluded and concomitant vitamin A and other drug administration as well as common factors, ”
KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease. (2006, background): “The afety of vitamin E also must be considered: a ecent meta-analysis in the non–kidney-disease opulation suggested that doses of 400 U/d or ore of vitamin E were associated with an inrease in all-cause mortality.(238)”
Nutrient Benefits of Quail (Coturnix Coturnix Japonica) Eggs (2012, neutral): “Caution is warranted (Miller et al., 2005; Bjelakovic et al., 2007; Mayo Clinic, 2011).”