Systematic Review and Meta-analysis Supplements for Primary and Secondary Prevention: Mortality in Randomized Trials of Antioxidant

By G. Bjelakovic, D. Nikolova, L. Gluud. 2009

2,292 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ff1bca3ee26f759cfb07615564c9ce33dd83973d

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Citations in the corpus

Acute exercise and oxidative stress: a 30 year history (2009, result): “To the contrary, and in accordance with the principle of hormesis, a low grade oxidative stress appears necessary for various physiological adaptations [35-37].”
Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. (2008, background): “Fat soluble antioxidant supplements may increase mortality [297].”
Stems cells and the pathways to aging and cancer. (2008, background): “…of data from 68 randomized trials showed no evidence that antioxidant dietary supplements had any beneficial effects on mortality but rather demonstrated, quite startlingly, that several common antioxidant dietary supplements actually increased the risk of death (Bjelakovic et al., 2007).”
2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. (2014, background): “, vitamins E, C, or beta carotene) should not be used for secondary prevention in patients with NSTE-ACS (254,255).”
The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology (2012, background): “like adding known antioxidants rarely are effective and are sometimes distinctly counter-productive [61].”
Antioxidants prevent health-promoting effects of physical exercise in humans (2009, background): “Moreover, antioxidant use in type 2 diabetics has been linked to increased prevalence of hypertension (31) and use of antioxidant supplements has recently been proposed to increase overall mortality in the general population (32).”
Oxidative stress, aging, and diseases (2018, background): “110 These conflicting findings can lead to the conclusion that vitamins cannot be used as effective antioxidant therapeutic agents.”
Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases (2015, result): “The results showed that vitamin C and selenium had no significant effect on mortality; treatment with β-carotene, vitamin A, and vitamin E may increase mortality [153].”