Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases.

By Asima Bhattacharyya, Ranajoy Chattopadhyay, S. Mitra, S. Crowe. Physiological Reviews, 2014

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Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling (2017, background): “Zinc is also crucial for the balance between the different T-cell subsets (Foster and Samman 2012; Haase and Rink 2014; Bonaventura et al. 2015).”
Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “Beyond that, various drugs and xenobiotics have been reported to enhance the production of free radicals in the gut [27].”
Zinc in Infection and Inflammation (2017, background): “Air pollutants, tobacco smoke, ionizing and nonionizing radiations, foods and drugs, as well as xenobiotics can all contribute to oxidative stress [63].”
Role of ROS and Nutritional Antioxidants in Human Diseases (2018, background): “Although the exact etiology of IBD remains unclear, the underlying pathologies can be partially attributed to excess ROS formation (Zhu and Li, 2012; Bhattacharyya et al., 2014).”
Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases (2020, background): “…which, in turn, causes oxidative stress and irreversible changes in cell compounds, including proteins, carbohydrates and lipids, in addition to being able to disrupt normal cellular-signaling mechanisms (Birben et al., 2012; Zal et al., 2014; Salehi et al., 2018; Sharifi-Rad et al., 2018).”