Langerhans cells arise from monocytes in vivo

By Florent Ginhoux, F. Tacke, V. Angeli, M. Bogunovic, M. Loubeau, Xu-ming Dai, E. Stanley, G. Randolph, Miriam Merad. Nature Immunology, 2006

764 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/decc24d854a5b6971ed9e4b7cb6556d2b42c0f16

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Florent Ginhoux
2. Steffen Jung
3. F. Geissmann
4. Miriam Merad
5. Eric G. Pamer
6. C. Varol
7. C. Shi
8. J. Hamilton

Citations in the corpus

• Monocytes give rise to mucosal, but not splenic, conventional dendritic cells (2007, background): “Despite this critical position in the MP diff erentiation pathway, the in vivo biology of this ephemeral MP intermediate (13, 15, 16, 35, 42, 43) remains poorly understood.”
• Monocyte recruitment during infection and inflammation (2011, background): “Depletion of resident cells by a variety of experimental approaches has been used to demonstrate that, under certain conditions, circulating monocytes can reconstitute Langerhans cell populations in the ski”
• Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas (2010, background): “When we compared marrow monocytes before and after culture in GM-CSF and IL-4 (Figure 1C, left, days 0 and 4) to spleen monocytes and classical DCs (Figure 1C, right panels), we found that Mo-DCs like spleen DCs lacked M-CSF receptor or CD115, a key receptor for monocyte development, whereas both ma”
• Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. (2007, background): “Interestingly, monocytes have been demonstrated to represent LC precursors both under steady state and during inflammation (Ginhoux et al., 2006; Merad et al., 2002).”
• Monocyte-mediated defense against microbial pathogens. (2008, background): “In a murine model of UV-induced skin injury, Ly6C+ murine monocytes labeled with latex particles enter the skin within four days, proliferate, and differentiate into MHC class II+langerin+ LCs (36) (Figure 1).”
• Repertoire of microglial and macrophage responses after spinal cord injury (2011, background): “They give rise to resident conventional dendritic cells in non-lymphoid organs, such as the lung, skin and gastrointestinal tract, but not in the splee”
• Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells (2008, background): “However, during inflammation, circulating monocytes have been shown to replenish epidermal LC population”
• The origin and development of nonlymphoid tissue CD103+ DCs (2009, background): “, 2000), and monocytes can repopulate the Langerhans cell (LC) compartment in an inflamed epidermis (Ginhoux et al., 2006) and give rise to intestinal CX3CR1+ cDCs in the steady state (Bogunovic et al.”
• Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis (2007, background): “Interestingly, despite the normalized level of circulating MOs from day 2 after injury, no delayed recruitment was observed, suggesting that signals governing MO recruitment are only transiently expressed by the damaged tissue, as was recently documented in ultravioletinjured skin (48).”
• Steady-state and inflammatory dendritic-cell development (2007, background): “Although the lack of macrophage colony-stimulating factor ( M-CSF ; also known as CSF1) initially seemed to have little influence on the relative amounts of DCs in lymphoid tissues, recent studies have shown that mice lacking the M-CSF receptor (M-CSFR) are deficient in both monocytes and skin LC”
• The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Importantly, in inflammatory conditions that lead to severe LC depletion and damage of the epidermal-dermal basal membrane, LCs are repopulated by blood-borne monocytes (43).”
• Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow (2007, background): “, and mice lacking M-CSF or its receptor (M-CSFR) have relatively normal numbers of steady-state lymphoid tissue DCs, whereas monocytes and epidermal Langerhans cells do not develop in these mic”