Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells

By Miriam Merad, Florent Ginhoux, M. Collin. Nature reviews. Immunology, 2008

871 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fe16f8d5a31267d9005f95893e6965a3d82da42c

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In Immunology

Citations in the corpus

Skin immune sentinels in health and disease (2009, background): “A comprehensive review on Langerhans cells has been recently publishe”
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Epidermal LCs are the DCs that populate the epidermal layer of the skin (34).”
Transition from inflammation to proliferation: a critical step during wound healing (2016, background): “Increased epidermal LCs has been observed at wound edges during early phases of normal wound healing, although the exact protective mechanism of these cells is unknown [26, 27].”
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells (2010, background): “These strains also have other immune and hematopoietic abnormalities because of the actions of Irf8 in other cell types dermal DCs (Merad et al., 2008).”
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages (2012, background): “Similar to most DCs, LCs are well equipped to capture, process, and present peptide-bound MHC complexes on the cell surface and migrate from the epidermis to the skin-draining lymph nodes to present cutaneous antigens to T lymphocytes (Merad et al., 2008; Romani et al., 2010).”
The origin and development of nonlymphoid tissue CD103+ DCs (2009, background): “RESULTS Two phenotypically distinct nonlymphoid tissue cDC subsets Langerin, which is highly expressed on the surface of epidermal LCs in mice and humans, was initially thought to be a specific marker for LCs in the skin (Merad et al., 2008).”
Signalling through C-type lectin receptors: shaping immune responses (2009, background): “By contrast, the expression of other CLRs is restricted to specific DC subsets with specialized functions; langerin (also known as CLEC4K and CD207) expression is restricted to Langerhans cells and a dermal DC subset 84 , whereas blood DC antigen 2 protein (BDCA2; also known as CLEC4C) is expressed ”
Human papillomavirus molecular biology and disease association (2015, background): “Human Langerhans cells are known to prime and cross prime naive CD8+ cells [244] although recent data from the mouse [49] suggest that in the skin, the important cross presenting antigen presenting cells are Langerin-positive and CD103positive dendritic cells, which may be of dermal origin.”