Monocyte-mediated defense against microbial pathogens.

By N. Serbina, Ting Jia, T. Hohl, Eric G. Pamer. Annual Review of Immunology, 2008

1,205 citations recorded by the source corpus.

Subfields: Immunology, Parasitology

View Paper: https://www.semanticscholar.org/paper/8f4bef0624e00a8a1276049945931789a5feaba8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. TA Wynn
2. J. Pollard
3. P. Murray
4. R. Noy
5. P. Italiani
6. D. Boraschi
7. Binzhi Qian
8. V. Bronte

In Parasitology

1. TA Wynn

Citations in the corpus

• Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors (2010, neutral): “Blood monocytes are bone marrow-derived phagocytes involved in the innate response to bacterial, fungal, parasitic, and viral infection (Barbalat et al., 2009; Gupta et al., 2001; Im Serbina et al., 2009; Serbina et al., 2008; Ströher et al., 2001).”
• Protective and pathogenic functions of macrophage subsets (2011, background): “Tissue stress, including acute and chronic infection, as well as sterile inflammation , drives the production of monocytes and neutrophils in a process that is dependent on cytokines such as granulocyte colony stimulating factor (G-CSF) and chemokines including CC-chemokine ligand 2 (CCL2) and CCL5”
• Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases (2014, background): “Functional properties of mouse monocyte subsets As shown in Figure 1, mouse Ly6C monocytes have a high antimicrobial capability due to their potent capacity for phagocytosis, secrete ROS, TNFα, nitric oxide, IL-1β, little IL-10 upon bacterial infection [17] and large amount of type 1 interferon (IFN”
• CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages (2015, background): “Furthermore, loss of CCL2 signaling in mouse models severely depresses the numbers of circulating monocytes and increases susceptibility to infection (Serbina et al., 2008).”
• Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells (2011, background): “In addition to CD8+ T cells, CCL2 attracts monocytes and macrophages to sites of inflammation (Serbina et al., 2008) and cancer (Sozzani et al., 1995).”
• From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “In some circumstances, monocytes can trigger and polarize T-cell responses (27, 28) and may also contribute to angiogenesis and atherogenesis (29).”
• Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression (2014, background): “Upon stimulation, monocytes exhibit large-scale gene transcription with concomitant cytokine production, enhanced antigen processing, and migration (11, 12).”
• Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal (2013, background): “…and infected tissues in order to recruit neutrophils 362 Cell 153, 362–375, April 11, 2013 ª2013 Elsevier Inc. within a few hours and ‘‘inflammatory’’ lymphocyte antigen 6c (Ly6C)+ monocytes 1 day later, herein initiating a cellular immune response (Auffray et al., 2009b; Serbina et al., 2008).”
• Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis (2012, neutral): “, 2010) and poised to traffic to sites of infection and inflammation (Geissmann et al., 2003; Serbina et al., 2008).”
• Origin of monocytes and macrophages in a committed progenitor (2013, background): “Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.”
• Blood monocytes: development, heterogeneity, and relationship with dendritic cells. (2009, background): “Murine Ly6C+ (Gr1+) monocytes are selectively recruited to inflamed tissues and lymph nodes in vivo, produce high levels of TNF-α and IL-1 during infection or tissue damage, and were termed inflammatory monocytes (8, 10, 16, 69, 104, 128).”
• The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ (2011, background): “tuberculosis relies on T cells, and the main resistance to infection is attributed to the production of IFN-γ by CD8 + T cells and T H 1 effector cell”
• The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and survival of Ly6C− monocytes (2011, neutral): “and can differentiate into antigen-presenting cells that produce tumor necrosis factor, nitric oxide and reactive oxygen specie”