Monocyte recruitment during infection and inflammation

By C. Shi, Eric G. Pamer. Nature reviews. Immunology, 2011

2,905 citations recorded by the source corpus.

Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave the bloodstream and migrate into tissues where, following conditioning by local growth factors, pro-inflammatory cytokines and microbial products, they differentiate into macrophage or dendritic cell populations. Recruitment of monocytes is essential for effective control and clearance of viral, bacterial, fungal and protozoal infections, but recruited monocytes also contribute to the pathogenesis of inflammatory and degenerative diseases. The mechanisms that control monocyte trafficking under homeostatic, infectious and inflammatory conditions are being unravelled and are the focus of this Review.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/19dd69ec20707377066a70f491320518c8027244

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In Immunology

1. P. Italiani
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4. O. Harrison
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Citations in the corpus

• Inflammation, Fracture and Bone Repair (2016, background): “Resident macrophages are found in most tissues throughout life whereas recruited inflammatory macrophages, derived from circulating blood monocytes, infiltrate sites of inflammation and are short-lived [40,67].”
• Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice (2016, background): “CCL2, CCL7, and CCL12, which are ligands for CCR2, as well as GM-CSF, a macrophage growth factor, are involved in IMM recruitment (Shi and Pamer, 2011; Song et al., 2015).”
• Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “APC: antigen-presenting cell monocyte subsets, early monocytes are a homogeneous subset with expression of both CXCR4 and CCR2 (16).”
• The biphasic function of microglia in ischemic stroke (2017, positive): “On the other hand, however, microglia also contribute to tissue repair and remodeling by clearing up debris and producing anti-inflammatory cytokines and growth factors (Shi and Pamer, 2011).”
• Developmental and Functional Heterogeneity of Monocytes. (2018, background): “However, since the MDP may contain committed monocyte- and cDC1-precursors it may well be that the MDP in Irf8-deficient mice only consist of cDC2- committed precursors and may in fact comprise of different pool of cells as compared to wild-type MDP.”
• Homeostatic immunity and the microbiota (2017, positive): “Tonic sensing of minute concentrations of LPS, a setting that can reflect microbiota fluctuation, drives CCR2-dependent emigration of monocytes from the bone marrow (Shi and Pamer, 2011).”
• Macrophage heterogeneity in tissues: phenotypic diversity and functions (2014, background): “In response to inflammation and infection, bone marrow-derived blood-borne monocytes give rise to cells that remain within the circulation or enter tissues, giving rise to both macrophages and dendritic cells (DCs) (7); ‘elicited’ macrophages often show enhanced turnover at local sites (8).”
• Macrophage plasticity, polarization, and function in health and disease (2018, background): “In addition, HIV-infected macrophages have been implicated in the elimination of effector CD8+ T cells (Alfano et al., 2013; Burdo et al., 2015; Cassol et al., 2010; Shi & Pamer, 2011; Sica et al., 2015).”
• Mesenchymal stem cell-macrophage crosstalk and bone healing (2018, background): “During infection and inflammation, their numbers increase greatly via homing of regional and circulating monocyte precursors to the affected area [19].”